MFSD6 and SSMEM1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MFSD6	SSMEM1
Name		major facilitator superfamily domain containing 6	serine rich single-pass membrane protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	None
GWAS		Arthritis (juvenile idiopathic) ( 33106285 ) Daytime sleep phenotypes ( 27126917 ) Estimated glomerular filtration rate ( 31015462 ) Medication use (thyroid preparations) ( 31015401 ) Platelet count ( 32888494 )	Neurological blood protein biomarker levels ( 31320639 )
Novel Interactors		7 novel interactors: AKAP19 ANKAR HIBCH MSTN OSGEPL1 STAT1 WDR75	None recorded
Interacting Genes		37 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 FAM209A GJA8 GJB2 GPR152 GPR42 GPX8 LY6E NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SLC60A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2	99 interacting genes: ALG3 APOA2 AQP1 AQP10 AQP3 ARLN ATP6V0C BET1 BLCAP C11orf24 C1QL4 C5 CCL4L2 CDIPT CDS2 CLRN2 CMTM7 CSGALNACT2 CTSA CXCL16 CXCL9 CYB561 CYBC1 DEFB103A DEFB103B DEFB121 EFNA5 EMD ERG28 ERMP1 FAM3C FATE1 FDPS FPR2 GJB2 GPHB5 GPR151 HMOX2 JAGN1 LAT LEPROTL1 LHFPL5 LNPEP MARCHF2 MCRS1 MFSD12 MFSD6 MIP MMD2 MS4A13 NINJ2 NIPAL4 NRM PGAP2 PLPP1 PLPP4 PLPP6 PLPPR2 RHD RTP2 RUSF1 S1PR5 SERP1 SLC35A1 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC61A1 STX8 TAP1 TAS2R10 TLCD1 TM6SF2 TMEM128 TMEM14A TMEM14C TMEM203 TMEM218 TMEM222 TMEM239 TMEM243 TMEM45A TMEM60 TMEM86A TMEM86B TMEM97 TMPPE TNF TRARG1 UNC93B1 UPK1B VAMP4 YIPF6 ZFPL1
Entrez ID		54842	136263
HPRD ID		13369	14060
Ensembl ID		ENSG00000151690	ENSG00000165120
Uniprot IDs		B7Z7Y2 Q6ZSS7	A0A3B3ISA2 Q8WWF3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Gap Junction-mediated Intercellular Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Phosphatidate Phosphatase Activity Transmembrane Transport Glycerol Transmembrane Transport Carbohydrate Transport Water Transport Polyol Transmembrane Transport Phospholipid Metabolic Process Alkenylglycerophosphocholine Hydrolase Activity Fluid Transport Phospholipid Dephosphorylation Plasma Membrane Channel Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Diacylglycerol Diphosphate Phosphatase Activity Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transport Carbohydrate Transmembrane Transport Amide Transport Glycerol Channel Activity Lipid Phosphatase Activity Renal Water Absorption One-carbon Compound Transport Urea Transmembrane Transporter Activity Farnesyl Diphosphate Metabolic Process Gap Junction-mediated Intercellular Transport Sphingosine-1-phosphate Phosphatase Activity CCR6 Chemokine Receptor Binding Antigen Processing And Presentation Of Peptide Antigen Response To Bacterium Chemotaxis Lysophosphatidic Acid Phosphatase Activity Inorganic Cation Transmembrane Transporter Activity Renal Water Transport Neutrophil Differentiation Glutamine Transport L-glutamine Transmembrane Transporter Activity Locomotion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Ammonium Channel Activity Urea Transmembrane Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane