MFSD6 and TMEM258

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MFSD6	TMEM258
Name		major facilitator superfamily domain containing 6	transmembrane protein 258
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Protein Binding	Protein Binding Oligosaccharyltransferase Complex Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	Protein Glycosylation Protein N-linked Glycosylation Inflammatory Response Response To Endoplasmic Reticulum Stress Epithelial Cell Apoptotic Process
Pathways		None	Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
GWAS		Arthritis (juvenile idiopathic) ( 33106285 ) Daytime sleep phenotypes ( 27126917 ) Estimated glomerular filtration rate ( 31015462 ) Medication use (thyroid preparations) ( 31015401 ) Platelet count ( 32888494 )	Asthma ( 31959851 31619474 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Eosinophil count ( 32888494 ) Hematocrit ( 27863252 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) Male-pattern baldness ( 28196072 ) QRS duration ( 27659466 ) Red blood cell count ( 32888494 27863252 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 ) Reticulocyte count ( 32888494 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352 ) Serum metabolite levels ( 31636271 33031748 ) Serum metabolite levels (CMS) ( 31636271 ) Serum metabolite ratios in chronic kidney disease ( 29545352 )
Novel Interactors		7 novel interactors: AKAP19 ANKAR HIBCH MSTN OSGEPL1 STAT1 WDR75	1 novel interactors: FADS2
Interacting Genes		37 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 FAM209A GJA8 GJB2 GPR152 GPR42 GPX8 LY6E NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SLC60A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2	4 interacting genes: ARL6IP1 IER3IP1 MFSD6 UBQLN1
Entrez ID		54842	746
HPRD ID		13369	12602
Ensembl ID		ENSG00000151690	ENSG00000134825
Uniprot IDs		B7Z7Y2 Q6ZSS7	P61165
PDB IDs		Not available	6S7O 6S7T 8B6L 8PN9
GO Terms Enriched among Interactors		Membrane Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Gap Junction-mediated Intercellular Transport	Positive Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Endoplasmic Reticulum Acyl-CoA Desaturase Activity Stearoyl-CoA 9-desaturase Activity Endoplasmic Reticulum Organization Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Extracellular Matrix Constituent Secretion Arachidonate Metabolite Production Involved In Inflammatory Response Positive Regulation Of L-glutamate Import Across Plasma Membrane Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Sec61 Translocon Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Extracellular Matrix Constituent Secretion Regulation Of L-glutamate Import Across Plasma Membrane Type B Pancreatic Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cellular Response To Oxidative Stress Production Of Molecular Mediator Involved In Inflammatory Response Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Endoplasmic Reticulum Membrane Organization Regulation Of Programmed Cell Death Endoplasmic Reticulum Tubular Network Organization Regulation Of Apoptotic Process Cotranslational Protein Targeting To Membrane Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Fibroblast Apoptotic Process Insulin Metabolic Process Enteroendocrine Cell Differentiation Endoplasmic Reticulum Tubular Network Positive Regulation Of Amino Acid Transport Regulation Of Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Positive Regulation Of Extracellular Matrix Organization