MFSD6 and SLC18A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MFSD6	SLC18A1
Description		major facilitator superfamily domain containing 6	solute carrier family 18 member A1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Terminal Bouton Synapse Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse
	Molecular Function	Protein Binding	Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Monoamine:proton Antiporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	Neurotransmitter Transport Serotonin Transport Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Dopamine Transport Xenobiotic Transport Serotonin Uptake Norepinephrine Uptake Establishment Of Localization In Cell Transmembrane Transport Dopamine Uptake Proton Transmembrane Transport
Pathways
Drugs			Reserpine Norepinephrine Ephedra sinica root MMDA Metamfetamine
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31015462) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Cholesterol ( 31902109) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertriglyceridemia ( 23505323) Major depressive disorder (broad) ( 20038947) Metabolic syndrome ( 30382898 31589552) Persistent hepatitis B virus infection ( 27244555) Pulse pressure ( 27841878) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 18193046 24886709)
Interacting Genes		37 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 FAM209A GJA8 GJB2 GPR152 GPR42 GPX8 LY6E NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SLC60A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2	88 interacting genes: ADGRE2 AGTRAP ANKRD46 APOL2 BRICD5 BTN2A2 C1GALT1 C2CD2L CCL4 CCL4L2 CD81 CNIH1 COL4A5 CTSA CXCL16 CYB561D2 ERMP1 FAM3C FCER1G FXYD3 GIMAP1 GJB2 GPR151 HTATIP2 INSIG2 LAT MALL MARCHF2 MFSD6 MGAM MGLL MIP MS4A1 MS4A13 NEU1 NRM OLFM4 ORMDL1 PEX16 PLP1 PLP2 PMP22 PNLIPRP1 RABAC1 RPRM SCD SEC22A SELENOK SERP1 SLC30A2 SLC30A3 SLC30A8 SLC35B4 SLC35G1 SLC38A7 SLC39A2 SMCO4 SMIM1 STX2 STX7 STX8 SYNGR1 TECR TFRC TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM218 TMEM239 TMEM42 TMEM60 TMEM65 TMEM86A TMEM97 TSPO2 UPK1B UPK2 VAMP5 VAPA VAPB VTI1B YIPF1 YIPF4 YIPF6
Entrez ID		54842	6570
HPRD ID		13369	01897
Ensembl ID		ENSG00000151690	ENSG00000036565
Uniprot IDs		B7Z7Y2 Q6ZSS7	P54219 Q96GL6
PDB IDs			8TGG 8TGH 8TGI 8TGJ 8TGK 8TGL 8TGM 8TGN
Enriched GO Terms of Interacting Partners?		Membrane Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Gap Junction-mediated Intercellular Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Membrane Docking Protein Binding SNAP Receptor Activity Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Membrane Organization Zinc Ion Transmembrane Transporter Activity Vesicle-mediated Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Membrane Fusion Zinc Ion Import Into Organelle Cellular Localization Endomembrane System FFAT Motif Binding Monoatomic Cation Transmembrane Transporter Activity SNARE Complex Zinc Ion Import Into Lysosome Vesicle Fusion Organelle Membrane Fusion Lysosome Zinc:proton Antiporter Activity COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Vesicle Docking Establishment Of Localization In Cell Vesicle SNARE Binding Intracellular Transport Fatty Acid Biosynthetic Process Gap Junction-mediated Intercellular Transport Cytoplasmic Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole Endoplasmic Reticulum Localization Vesicle Fusion With Golgi Apparatus Organelle Fusion Golgi Vesicle Transport Transmembrane Transport Lysosomal Membrane Vacuolar Transmembrane Transport Synaptic Vesicle Golgi Trans Cisterna Secretory Vesicle Golgi Medial Cisterna Metal Ion Transport
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