MFSD6 and MSTN

		MFSD6	MSTN
Description		major facilitator superfamily domain containing 6	myostatin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Skeletal Muscle Satellite Cell Differentiation Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Skeletal Muscle Tissue Regeneration Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Glucocorticoid Response To Electrical Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Trophoblast Cell Migration Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation
Pathways			FOXO-mediated transcription of cell cycle genes
Drugs			Stamulumab
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31015462) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494)	Daytime sleep phenotypes ( 27126917) Schizophrenia ( 34099189)
Interacting Genes		37 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 FAM209A GJA8 GJB2 GPR152 GPR42 GPX8 LY6E NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SLC60A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2	6 interacting genes: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2
Entrez ID		54842	2660
HPRD ID		13369	03474
Ensembl ID		ENSG00000151690	ENSG00000138379
Uniprot IDs		B7Z7Y2 Q6ZSS7	O14793 Q53S46
PDB IDs			5F3B 5F3H 5NTU 5NXS 6UMX
Enriched GO Terms of Interacting Partners?		Membrane Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Gap Junction-mediated Intercellular Transport	Activin Binding Regulation Of Activin Receptor Signaling Pathway Roof Of Mouth Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization TRC Complex Titin-telethonin Complex Titin Z Domain Binding Muscle Cell Development Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Anterior/posterior Pattern Specification Venous Blood Vessel Development Activin Receptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BAT3 Complex Binding Myosin Filament Assembly FATZ Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway
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