TMEM258 and IER3IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM258	IER3IP1
Description		transmembrane protein 258	immediate early response 3 interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle
	Molecular Function	Protein Binding Oligosaccharyltransferase Complex Binding	Protein Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Inflammatory Response Response To Endoplasmic Reticulum Stress Epithelial Cell Apoptotic Process	Type B Pancreatic Cell Differentiation Positive Regulation Of Extracellular Matrix Constituent Secretion Chromatin Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Brain Development Negative Regulation Of Cell Population Proliferation Gene Expression Protein Transport Organ Growth Glucose Homeostasis Negative Regulation Of Apoptotic Process Cell Maturation Positive Regulation Of Protein Secretion Insulin Metabolic Process Regulation Of Fibroblast Apoptotic Process
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Male-pattern baldness ( 28196072) QRS duration ( 27659466) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Resting heart rate ( 27798624) Reticulocyte count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352)	Fruit consumption ( 32066663)
Interacting Genes		4 interacting genes: ARL6IP1 IER3IP1 MFSD6 UBQLN1	43 interacting genes: AIG1 C19orf18 CDIPT CERS2 CERS4 CSNK2B CST1 DPM3 EBP ELOVL4 ERMP1 FAM210B FCER1G GJB1 GOSR2 GPR42 HERPUD2 JAGN1 KCNA1 MOSPD3 PEX12 PIGP PLP1 POMK RGS2 SCN3B SLC30A4 TK1 TM4SF18 TMEM128 TMEM14A TMEM14B TMEM167A TMEM237 TMEM258 TMEM80 TMEM86B TMPPE TMX2 TRHR UBQLN1 YIPF4 ZFYVE27
Entrez ID		746	51124
HPRD ID		12602	13727
Ensembl ID		ENSG00000134825	ENSG00000134049
Uniprot IDs		P61165	Q9Y5U9
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Endoplasmic Reticulum Acyl-CoA Desaturase Activity Stearoyl-CoA 9-desaturase Activity Endoplasmic Reticulum Organization Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Extracellular Matrix Constituent Secretion Arachidonate Metabolite Production Involved In Inflammatory Response Positive Regulation Of L-glutamate Import Across Plasma Membrane Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Sec61 Translocon Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Extracellular Matrix Constituent Secretion Regulation Of L-glutamate Import Across Plasma Membrane Type B Pancreatic Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cellular Response To Oxidative Stress Production Of Molecular Mediator Involved In Inflammatory Response Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Endoplasmic Reticulum Membrane Organization Regulation Of Programmed Cell Death Endoplasmic Reticulum Tubular Network Organization Regulation Of Apoptotic Process Cotranslational Protein Targeting To Membrane Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Fibroblast Apoptotic Process Insulin Metabolic Process Enteroendocrine Cell Differentiation Endoplasmic Reticulum Tubular Network Positive Regulation Of Amino Acid Transport Regulation Of Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Positive Regulation Of Extracellular Matrix Organization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipid Biosynthetic Process Sphingosine N-acyltransferase Activity Membrane Lipid Metabolic Process Lipid Metabolic Process Response To Endoplasmic Reticulum Stress
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