TMEM258 and ARL6IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM258	ARL6IP1
Description		transmembrane protein 258	ARL6 interacting reticulophagy regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Cytoplasm Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding Oligosaccharyltransferase Complex Binding	Protein Binding Identical Protein Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Inflammatory Response Response To Endoplasmic Reticulum Stress Epithelial Cell Apoptotic Process	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Male-pattern baldness ( 28196072) QRS duration ( 27659466) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Resting heart rate ( 27798624) Reticulocyte count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352)	Caffeine consumption from coffee or tea ( 33287642) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: ARL6IP1 IER3IP1 MFSD6 UBQLN1	78 interacting genes: ACSF2 AQP6 ARL4D ARL6 BCL2L13 C19orf18 CERT1 DIABLO DRC4 EHD3 EMP1 F2RL1 FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GOLPH3L GORASP2 GPR151 GPR152 HGS HMGCL HSD17B13 INPP5K LMNA MCEMP1 MGST3 MIEF2 MTERF3 MYG1 NAPB NDRG4 NTAQ1 NUDT3 PAM16 PBX3 PICK1 PTPN9 RAB33A REEP6 RETREG3 RNF5 SDCBP SENP2 SHISA5 SHMT2 SLC10A6 SLC13A1 SLC35H1 SLC61A1 SLC71A2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX2 SNX3 SNX4 SNX8 SPG21 STARD4 SUCLA2 TARS2 TFAM TMED8 TMEM14B TMEM248 TMEM258 TUFM UBE2I VMA21 WDFY2 WIPI2 YIPF4 ZFYVE21 ZNF391
Entrez ID		746	23204
HPRD ID		12602	09641
Ensembl ID		ENSG00000134825	ENSG00000170540
Uniprot IDs		P61165	Q15041
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Endoplasmic Reticulum Acyl-CoA Desaturase Activity Stearoyl-CoA 9-desaturase Activity Endoplasmic Reticulum Organization Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Extracellular Matrix Constituent Secretion Arachidonate Metabolite Production Involved In Inflammatory Response Positive Regulation Of L-glutamate Import Across Plasma Membrane Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Sec61 Translocon Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Extracellular Matrix Constituent Secretion Regulation Of L-glutamate Import Across Plasma Membrane Type B Pancreatic Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cellular Response To Oxidative Stress Production Of Molecular Mediator Involved In Inflammatory Response Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Endoplasmic Reticulum Membrane Organization Regulation Of Programmed Cell Death Endoplasmic Reticulum Tubular Network Organization Regulation Of Apoptotic Process Cotranslational Protein Targeting To Membrane Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Fibroblast Apoptotic Process Insulin Metabolic Process Enteroendocrine Cell Differentiation Endoplasmic Reticulum Tubular Network Positive Regulation Of Amino Acid Transport Regulation Of Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Positive Regulation Of Extracellular Matrix Organization	Lipid Binding Phosphatidylinositol Binding Cellular Localization Establishment Of Protein Localization Retromer Complex Intracellular Transport Protein Transport Membrane Establishment Of Localization In Cell Leptin Receptor Binding Localization Within Membrane Intracellular Protein Transport Early Endosome To Golgi Transport Intracellular Protein Localization Vesicle-mediated Transport To The Plasma Membrane Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Endosome Phosphatidylinositol-4-phosphate Binding Transferrin Receptor Binding Negative Regulation Of Early Endosome To Late Endosome Transport Endosomal Transport Endocytic Recycling Cytosolic Transport Early Endosome Membrane Phosphatidylinositol-3-phosphate Binding Protein Targeting To Golgi Apparatus Protein Binding Mitochondrial Matrix Early Endosome Retromer, Tubulation Complex Golgi Vesicle Budding Cargo Adaptor Activity Establishment Of Protein Localization To Plasma Membrane Insulin Receptor Binding Vesicle-mediated Transport Organelle Organization Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport Succinate Metabolic Process Lamellipodium Morphogenesis Epidermal Growth Factor Receptor Binding Vesicle Budding From Membrane Protein Localization To Membrane Vesicle Organization Positive Regulation Of Exocytosis Regulation Of Establishment Of Protein Localization Membrane Organization Golgi Cisterna Regulation Of Protein Localization
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