PLCB2 and MAP2K3

Number of citations of the paper that reports this interaction (PMID 12054652)
1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		PLCB2	MAP2K3
Gene Name		phospholipase C, beta 2	mitogen-activated protein kinase kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleoplasm Cytosol Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding	Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Phospholipid Metabolic Process Activation Of Phospholipase C Activity Synaptic Transmission Metabolic Process Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Sensory Perception Of Bitter Taste	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cytokine Biosynthetic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Cardiac Muscle Contraction
Pathways		G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses	MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7	20 interactors: ALDOC APP ARRB1 DCTN1 DYRK1B ELK1 LRRK2 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 PLCB2 RPL13 SMAD7 TAOK1 TAOK2 TINF2
Entrez ID		5330	5606
HPRD ID		04985	03816
Ensembl ID		ENSG00000137841	ENSG00000034152
Uniprot IDs		Q00722 Q59F77	P46734 Q6FI23
PDB IDs		2FJU 2ZKM
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Ion Transport Dopamine Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transporter Activity Regulation Of Cellular Protein Metabolic Process Cardiac Muscle Contraction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Heart Contraction Negative Regulation Of Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Catalytic Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cation Transport Regulation Of Intracellular Transport Regulation Of Calcium Ion Transport Into Cytosol Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Striated Muscle Contraction Regulation Of Phospholipase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Thrombin Receptor Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Positive Regulation Of Transferase Activity Toll-like Receptor Signaling Pathway	MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Activation Of MAPKK Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphate-containing Compound Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Activation Of Protein Kinase Activity Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Response To Stress Cellular Metabolic Process Cellular Protein Metabolic Process Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Regulation Of MAP Kinase Activity Cellular Response To Stress Cellular Protein Modification Process Signaling Regulation Of JNK Cascade Cell Communication
Tagcloud ?		adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcd1 plce potentiate quiescent react transduction tuned umbilical upcoming	alternate ask biogenesis cascades cytochrome discovered dissociation generating glycolysis hypoxic induces mapkkk metallochaperone mitogen oxidase oxphos possess prevents redox ros sco2 switches switching thioredoxin thr tigar trx xenografts
Tagcloud (Difference) ?		adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcd1 plce potentiate quiescent react transduction tuned umbilical upcoming	alternate ask biogenesis cascades cytochrome discovered dissociation generating glycolysis hypoxic induces mapkkk metallochaperone mitogen oxidase oxphos possess prevents redox ros sco2 switches switching thioredoxin thr tigar trx xenografts
Tagcloud (Intersection) ?