PLCB2 and TRPM7

Number of citations of the paper that reports this interaction (PMID 11941371)
121

Data Source:
HPRD (in vitro, two hybrid)

		PLCB2	TRPM7
Gene Name		phospholipase C, beta 2	transient receptor potential cation channel, subfamily M, member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Ruffle Plasma Membrane Integral Component Of Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding	Actin Binding Protein Serine/threonine Kinase Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Activation Of Phospholipase C Activity Synaptic Transmission Metabolic Process Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Sensory Perception Of Bitter Taste	Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Ion Transmembrane Transport Protein Autophosphorylation Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport
Pathways		G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses	Ion channel transport TRP channels Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7	9 interactors: ANXA1 EEF2 HIST3H3 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6
Entrez ID		5330	54822
HPRD ID		04985	10418
Ensembl ID		ENSG00000137841	ENSG00000092439
Uniprot IDs		Q00722 Q59F77	H0YLN8 Q96QT4
PDB IDs		2FJU 2ZKM
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Ion Transport Dopamine Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transporter Activity Regulation Of Cellular Protein Metabolic Process Cardiac Muscle Contraction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Heart Contraction Negative Regulation Of Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Catalytic Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cation Transport Regulation Of Intracellular Transport Regulation Of Calcium Ion Transport Into Cytosol Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Striated Muscle Contraction Regulation Of Phospholipase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Thrombin Receptor Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Positive Regulation Of Transferase Activity Toll-like Receptor Signaling Pathway	Inositol Phosphate Metabolic Process Lipid Catabolic Process Regulation Of Phospholipase Activity Alcohol Metabolic Process Cell-cell Signaling Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Synaptic Transmission Response To Cytokine Activation Of Phospholipase C Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cell Cycle Phase Transition Phospholipid Metabolic Process Positive Regulation Of Phospholipase Activity Organophosphate Metabolic Process Neutrophil Clearance Positive Regulation Of CD24 Biosynthetic Process Interleukin-15-mediated Signaling Pathway Negative Regulation Of Monocyte Extravasation Response To Interleukin-1 Positive Regulation Of Lipase Activity DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Activation Of Meiosis Involved In Egg Activation Lipid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Production Regulation Of G1/S Transition Of Mitotic Cell Cycle Defense Response To Nematode Negative Regulation Of Phospholipase A2 Activity Interleukin-12-mediated Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Activation Of Meiosis Negative Regulation Of Interleukin-8 Secretion Response To Interleukin-12 Response To Toxic Substance Phosphate-containing Compound Metabolic Process Positive Regulation Of Transport Prolactin Secretion Positive Regulation Of Acrosome Reaction Positive Regulation Of Prostaglandin Biosynthetic Process Response To Nematode Negative Regulation Of Phospholipase Activity Negative Regulation Of Cytokine Production Regulation Of Fertilization Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Response To Interleukin-15
Tagcloud ?		adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcd1 plce potentiate quiescent react transduction tuned umbilical upcoming	abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream
Tagcloud (Difference) ?		adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcd1 plce potentiate quiescent react transduction tuned umbilical upcoming	abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream
Tagcloud (Intersection) ?