PLCB2 and GCHFR

		PLCB2	GCHFR
Description		phospholipase C beta 2	GTP cyclohydrolase I feedback regulator
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GO Annotations	Cellular Component	Cytoplasm Cytosol G-protein Beta/gamma-subunit Complex Neuronal Dense Core Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Dendrite Nuclear Membrane Melanosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phospholipid Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding Phosphatidylinositol Phospholipase C Activity	Enzyme Inhibitor Activity Protein Binding GTP Cyclohydrolase Binding GTP Cyclohydrolase I Regulator Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste Release Of Sequestered Calcium Ion Into Cytosol	Negative Regulation Of Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors Sensory perception of sweet, bitter, and umami (glutamate) taste	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)	Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Triglycerides ( 30275531)
Interacting Genes		7 interacting genes: GNAQ MAP2K3 MAP2K6 NHERF1 SNCA TRPC3 TRPM7	1 interacting genes: GCH1
Entrez ID		5330	2644
HPRD ID		04985	03895
Ensembl ID		ENSG00000137841	ENSG00000137880
Uniprot IDs		Q00722 Q59F77 Q9BVT6	P30047
PDB IDs		2FJU 2ZKM	6Z80 6Z85 7ACC 7AL9 7ALA 7ALB 7ALC 7ALQ
Enriched GO Terms of Interacting Partners?		Response To Testosterone Regulation Of Phosphorus Metabolic Process NLRP1 Inflammasome Complex Assembly Response To Ketone Regulation Of Protein Kinase Activity Cellular Response To UV-B Regulation Of Phosphorylation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Calcium Channel Activity Response To Lipid MAP Kinase Kinase Activity Regulation Of Kinase Activity Response To Magnesium Ion Response To Light Stimulus Detection Of Abiotic Stimulus Response To UV-B Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Kinase Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Protein Serine Kinase Activity Regulation Of MAPK Cascade Extracellular Matrix Binding GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Regulation Of Cell Communication Response To Radiation Regulation Of Signaling Phototransduction Cellular Response To Stress S-methyl-5-thioadenosine Phosphorylase Activity Negative Regulation Of Centriole-centriole Cohesion Protein Serine/threonine Kinase Activity Cardiac Muscle Contraction Regulation Of Protein Phosphorylation Canonical Inflammasome Complex Assembly Pyroptotic Inflammatory Response Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Protein Kinase Inhibitor Activity Inorganic Ion Homeostasis Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Fibroblast Migration Calcium Ion Transmembrane Transport Renal Phosphate Ion Absorption Protein-containing Complex Assembly	GTP Cyclohydrolase I Activity G-protein Beta/gamma-subunit Complex Regulation Of Lung Blood Pressure Positive Regulation Of Nitric-oxide Synthase Activity Tetrahydrofolate Biosynthetic Process Regulation Of Removal Of Superoxide Radicals Regulation Of Nitric-oxide Synthase Activity Tetrahydrobiopterin Biosynthetic Process Phosphatidylinositol Phospholipase C Activity Sensory Perception Of Bitter Taste Folic Acid-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Dopamine Biosynthetic Process Regulation Of Response To Reactive Oxygen Species Neuron Projection Terminus Response To Pain Catecholamine Biosynthetic Process Regulation Of Cellular Response To Oxidative Stress Mitogen-activated Protein Kinase Binding Pteridine-containing Compound Biosynthetic Process Tetrahydrofolate Metabolic Process Nitric Oxide Biosynthetic Process Nervous System Process Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Posture Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Neuronal Dense Core Vesicle Phospholipase C Activity Phosphatidylinositol-mediated Signaling G-protein Beta/gamma-subunit Complex Binding Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Folic Acid-containing Compound Metabolic Process Regulation Of Response To Oxidative Stress Nitric Oxide Metabolic Process Regulation Of Superoxide Metabolic Process Reactive Nitrogen Species Metabolic Process Diol Metabolic Process Dopamine Metabolic Process Positive Regulation Of Heart Rate Pteridine-containing Compound Metabolic Process Sensory Perception Of Taste Biogenic Amine Biosynthetic Process Amine Biosynthetic Process Positive Regulation Of Heart Contraction Catecholamine Metabolic Process Phosphoric Diester Hydrolase Activity Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol System Process
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