EEF2

Gene Name		eukaryotic translation elongation factor 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane Membrane Aggresome Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Activator Activity Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Translation Translational Elongation Pathogenesis Gene Expression Positive Regulation Of Gene Expression Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation
Pathways		Synthesis of diphthamide-EEF2 Uptake and actions of bacterial toxins Translation Post-translational protein modification Peptide chain elongation Eukaryotic Translation Elongation Gamma carboxylation, hypusine formation and arylsulfatase activation Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS
Protein-protein Interactions		16 interactors: CCT2 CDKN2A DISC1 EEF2K EEF2KMT HNRNPD MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B TP53 TRPM7 UCHL5
Entrez ID		1938
HPRD ID		00561
Ensembl ID		ENSG00000167658
Uniprot IDs		B4DPU3 P13639
PDB IDs		3J3A
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Cell Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein RNA Catabolic Process Positive Regulation Of Cell Aging Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Growth Mitotic Nuclear Envelope Reassembly Apoptotic Process Cell Cycle Process Nuclear Envelope Reassembly Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Wnt Signaling Pathway Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Replicative Senescence Regulation Of Cell Growth Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of DNA Replication Cellular Response To Organic Substance Signaling Cell Communication Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of JAK-STAT Cascade Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Arrest Nuclear-transcribed MRNA Catabolic Process Cell Cycle MRNA Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Aromatic Compound Catabolic Process
Tagcloud ?		4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs