EEF2

Description		eukaryotic translation elongation factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Ribosome Plasma Membrane Membrane Aggresome Secretory Granule Lumen Synapse Extracellular Exosome Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding P53 Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding 5S RRNA Binding Hydrolase Activity Protein Kinase Binding Ribosome Binding Cadherin Binding Actin Filament Binding LncRNA Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Response To Ischemia Skeletal Muscle Contraction Translation Translational Elongation Response To Xenobiotic Stimulus Glial Cell Proliferation Response To Estradiol Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Response To Hydrogen Peroxide Response To Ethanol Positive Regulation Of Translation Response To Folic Acid Translation At Postsynapse Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Cytoplasmic Translation
Pathways		Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation
Drugs		Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Esketamine Moxetumomab pasudotox
Diseases
GWAS
Interacting Genes		28 interacting genes: ANXA1 CDKN2A CEBPA CREBBP DISC1 DSCAM DUX4 EEF2K ESR1 FILNC1 HNRNPD LCOR LINC01554 MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B PTEN RSPH1 RUNX1 SUMO2 TP53 TRPM7 UCHL5 XIAP
Entrez ID		1938
HPRD ID		00561
Ensembl ID		ENSG00000167658
Uniprot IDs		P13639
PDB IDs		4V6X 6D9J 6Z6M 6Z6N 8UKB 8XSX 8Y0W 8Y0X
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Transcription Coactivator Binding Protein Phosphatase Type 2A Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Development Regulation Of Growth Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Developmental Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Phosphatase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Cell Differentiation Nucleoplasm Protein Modification Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Estradiol Stimulus Response To Electrical Stimulus Negative Regulation Of Hemopoiesis Positive Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Multicellular Organismal Development Regulation Of Transcription By RNA Polymerase II Rhythmic Process DNA-templated Transcription Histone Deacetylase Binding Regulation Of Macromolecule Biosynthetic Process Organelle Organization Regulation Of Multicellular Organismal Process Transcription Corepressor Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Cytosol
Tagcloud ?