EEF2 and TRPM7

Number of citations of the paper that reports this interaction (PMID 14594813)
30

Data Source:
HPRD (in vitro)

		EEF2	TRPM7
Gene Name		eukaryotic translation elongation factor 2	transient receptor potential cation channel, subfamily M, member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane Membrane Aggresome Ribonucleoprotein Complex Extracellular Vesicular Exosome	Ruffle Plasma Membrane Integral Component Of Membrane
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Activator Activity Protein Kinase Binding Poly(A) RNA Binding	Actin Binding Protein Serine/threonine Kinase Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Translation Translational Elongation Pathogenesis Gene Expression Positive Regulation Of Gene Expression Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation	Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Ion Transmembrane Transport Protein Autophosphorylation Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport
Pathways		Synthesis of diphthamide-EEF2 Uptake and actions of bacterial toxins Translation Post-translational protein modification Peptide chain elongation Eukaryotic Translation Elongation Gamma carboxylation, hypusine formation and arylsulfatase activation Uptake and function of diphtheria toxin	Ion channel transport TRP channels Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CCT2 CDKN2A DISC1 EEF2K EEF2KMT HNRNPD MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B TP53 TRPM7 UCHL5	9 interactors: ANXA1 EEF2 HIST3H3 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6
Entrez ID		1938	54822
HPRD ID		00561	10418
Ensembl ID		ENSG00000167658	ENSG00000092439
Uniprot IDs		B4DPU3 P13639	H0YLN8 Q96QT4
PDB IDs		3J3A
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Cell Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein RNA Catabolic Process Positive Regulation Of Cell Aging Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Growth Mitotic Nuclear Envelope Reassembly Apoptotic Process Cell Cycle Process Nuclear Envelope Reassembly Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Wnt Signaling Pathway Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Replicative Senescence Regulation Of Cell Growth Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of DNA Replication Cellular Response To Organic Substance Signaling Cell Communication Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of JAK-STAT Cascade Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Arrest Nuclear-transcribed MRNA Catabolic Process Cell Cycle MRNA Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Aromatic Compound Catabolic Process	Inositol Phosphate Metabolic Process Lipid Catabolic Process Regulation Of Phospholipase Activity Alcohol Metabolic Process Cell-cell Signaling Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Synaptic Transmission Response To Cytokine Activation Of Phospholipase C Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cell Cycle Phase Transition Phospholipid Metabolic Process Positive Regulation Of Phospholipase Activity Organophosphate Metabolic Process Neutrophil Clearance Positive Regulation Of CD24 Biosynthetic Process Interleukin-15-mediated Signaling Pathway Negative Regulation Of Monocyte Extravasation Response To Interleukin-1 Positive Regulation Of Lipase Activity DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Activation Of Meiosis Involved In Egg Activation Lipid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Production Regulation Of G1/S Transition Of Mitotic Cell Cycle Defense Response To Nematode Negative Regulation Of Phospholipase A2 Activity Interleukin-12-mediated Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Activation Of Meiosis Negative Regulation Of Interleukin-8 Secretion Response To Interleukin-12 Response To Toxic Substance Phosphate-containing Compound Metabolic Process Positive Regulation Of Transport Prolactin Secretion Positive Regulation Of Acrosome Reaction Positive Regulation Of Prostaglandin Biosynthetic Process Response To Nematode Negative Regulation Of Phospholipase Activity Negative Regulation Of Cytokine Production Regulation Of Fertilization Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Response To Interleukin-15
Tagcloud ?		4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs	abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream
Tagcloud (Difference) ?		4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts untranslated utrs	abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together ubiquitous upstream
Tagcloud (Intersection) ?		translation