PEX14 and CAMTA1

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		PEX14	CAMTA1
Description		peroxisomal biogenesis factor 14	calmodulin binding transcription activator 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex Peroxisomal Importomer Complex	Nucleus Cytoplasm
	Molecular Function	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Protein Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Beta-tubulin Binding	DNA Binding Double-stranded DNA Binding Transcription Coregulator Activity Sequence-specific DNA Binding
	Biological Process	Protein Monoubiquitination Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To Reactive Oxygen Species Peroxisome Transport Along Microtubule Protein Unfolding Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Neuromuscular Process Controlling Balance Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Asthma ( 34103634 32296059 27182965) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 27117709 23535729 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol dependence ( 26365420) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Body size at age 10 ( 32376654) Crohn's disease ( 28067908) DHEAS levels ( 34748635) Diastolic blood pressure ( 30224653) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Intralaminar thalamic nuclei volume ( 34006833) Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309) Mean platelet volume ( 32888494 27863252) Morning person ( 30696823) Neurociticism ( 29500382) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Post bronchodilator FEV1 ( 26634245) Puberty onset ( 24770850) Puberty onset (breast development) ( 24770850) Rosacea symptom severity ( 29771307) Sleep duration (long sleep) ( 30846698) Stearic acid (18:0) levels ( 23362303) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Ulcerative colitis ( 28067908)
Interacting Genes		24 interacting genes: ACACB AFTPH CAMTA1 CBFA2T2 CENPK COPS4 FSD1 GET3 HDAC1 KDM5D MARF1 MED8 MTNR1A NEDD9 NFE2 NFKBIL1 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 TONSL ZHX1	1 interacting genes: PEX14
Entrez ID		5195	23261
HPRD ID		03477	16681
Ensembl ID		ENSG00000142655	ENSG00000171735
Uniprot IDs		O75381	A0A0C4DGL0 A0A8V8TPQ2 A0A8V8TQ65 A0A8V8TQ84 A0A8V8TQ87 A0A8V8TQX9 G3V297 Q9Y6Y1
PDB IDs		2W84 2W85 4BXU 9GAG	2CXK
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Protein Import Into Peroxisome Membrane Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Peroxisomal Membrane Peroxisome Membrane Targeting Sequence Binding Nucleoplasm Intracellular Protein Transmembrane Transport Protein Carrier Chaperone Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Nucleus Fatty Acid Oxidation Establishment Of Protein Localization To Membrane Protein Transmembrane Transport Protein Localization To Organelle Lipid Oxidation Nucleosome Disassembly Sin3-type Complex Protein-DNA Complex Disassembly Protein-containing Complex Negative Regulation Of Stem Cell Population Maintenance Receptor Recycling Circadian Rhythm Chromatin Organization Lipid Modification Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Disassembly Lactic Acid Secretion Intracellular Aspartate Homeostasis Nucleosomal DNA Binding Establishment Of Protein Localization To Organelle Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Receptor Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Peroxisomal Matrix Malonyl-CoA Biosynthetic Process Protein-containing Complex Organization Acetyl-CoA Carboxylase Activity Krueppel-associated Box Domain Binding Positive Regulation Of Immunological Synapse Formation Fatty Acid Beta-oxidation Peroxisome Matrix Targeting Signal-1 Binding	Protein Import Into Peroxisome Matrix, Translocation Peroxisome Transport Along Microtubule Protein Import Into Peroxisome Matrix, Docking Peroxisomal Importomer Complex Protein Import Into Peroxisome Matrix, Substrate Release Protein Transmembrane Transporter Activity Protein Unfolding Protein Import Into Peroxisome Matrix, Receptor Recycling Receptor Recycling Peroxisomal Membrane Transport Microtubule Anchoring Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Organization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Phosphatidylinositol-mediated Signaling Negative Regulation Of Protein Binding Intracellular Protein Transmembrane Transport Transmembrane Transport Beta-tubulin Binding Regulation Of Protein Binding Receptor Metabolic Process Phosphoric Diester Hydrolase Activity Protein Monoubiquitination Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of DNA-binding Transcription Factor Activity Peroxisomal Membrane Protein Transmembrane Transport Organelle Transport Along Microtubule Calcium Ion Transmembrane Import Into Cytosol
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