PEX14 and KDM5D

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		PEX14	KDM5D
Description		peroxisomal biogenesis factor 14	lysine demethylase 5D
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex Peroxisomal Importomer Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Protein Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Beta-tubulin Binding	DNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Dioxygenase Activity
	Biological Process	Protein Monoubiquitination Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To Reactive Oxygen Species Peroxisome Transport Along Microtubule Protein Unfolding Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly	T Cell Antigen Processing And Presentation Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Androgen Receptor Signaling Pathway
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import	HDMs demethylate histones
Drugs			Ascorbic acid
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Asthma ( 34103634 32296059 27182965) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 27117709 23535729 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)	Autism ( 32996047)
Interacting Genes		24 interacting genes: ACACB AFTPH CAMTA1 CBFA2T2 CENPK COPS4 FSD1 GET3 HDAC1 KDM5D MARF1 MED8 MTNR1A NEDD9 NFE2 NFKBIL1 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 TONSL ZHX1	3 interacting genes: H3-4 PCGF6 PEX14
Entrez ID		5195	8284
HPRD ID		03477	02464
Ensembl ID		ENSG00000142655	ENSG00000012817
Uniprot IDs		O75381	A0A384MR42 B4E1Y0 Q9BY66
PDB IDs		2W84 2W85 4BXU 9GAG	2E6R 2YQE
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Protein Import Into Peroxisome Membrane Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Peroxisomal Membrane Peroxisome Membrane Targeting Sequence Binding Nucleoplasm Intracellular Protein Transmembrane Transport Protein Carrier Chaperone Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Nucleus Fatty Acid Oxidation Establishment Of Protein Localization To Membrane Protein Transmembrane Transport Protein Localization To Organelle Lipid Oxidation Nucleosome Disassembly Sin3-type Complex Protein-DNA Complex Disassembly Protein-containing Complex Negative Regulation Of Stem Cell Population Maintenance Receptor Recycling Circadian Rhythm Chromatin Organization Lipid Modification Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Disassembly Lactic Acid Secretion Intracellular Aspartate Homeostasis Nucleosomal DNA Binding Establishment Of Protein Localization To Organelle Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Receptor Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Peroxisomal Matrix Malonyl-CoA Biosynthetic Process Protein-containing Complex Organization Acetyl-CoA Carboxylase Activity Krueppel-associated Box Domain Binding Positive Regulation Of Immunological Synapse Formation Fatty Acid Beta-oxidation Peroxisome Matrix Targeting Signal-1 Binding	Protein Import Into Peroxisome Matrix, Translocation Peroxisome Transport Along Microtubule Protein Import Into Peroxisome Matrix, Docking Peroxisomal Importomer Complex Spermatogonial Cell Division Protein Import Into Peroxisome Matrix, Substrate Release DNA Replication-dependent Chromatin Assembly Protein Transmembrane Transporter Activity Protein Unfolding Protein Import Into Peroxisome Matrix, Receptor Recycling Receptor Recycling Peroxisomal Membrane Transport Microtubule Anchoring Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Organization Chromatin Remodeling PcG Protein Complex PRC1 Complex Negative Regulation Of Protein Binding Intracellular Protein Transmembrane Transport Chromatin Organization Beta-tubulin Binding Regulation Of Protein Binding Receptor Metabolic Process Condensed Nuclear Chromosome Heterochromatin Protein Monoubiquitination
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