BORCS6 and PLA2G4A

Number of citations of the paper that reports this interaction (PubMedID 18330356)
0

Data Source:
BioGRID (two hybrid)

		BORCS6	PLA2G4A
Description		BLOC-1 related complex subunit 6	phospholipase A2 group IVA
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Cytoplasmic Side Of Lysosomal Membrane BORC Complex	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Lipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Hydrolase Activity Phosphatidylinositol-3-phosphate Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Carboxylic Ester Hydrolase Activity Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding
	Biological Process	Lysosome Localization Regulation Of Endosome Size Regulation Of Lysosome Size Organelle Transport Along Microtubule	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Monoacylglycerol Biosynthetic Process Glycerophospholipid Metabolic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Phospholipid Catabolic Process Positive Regulation Of Platelet Activation Lipid Catabolic Process Arachidonate Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Icosanoid Biosynthetic Process Glycerophospholipid Catabolic Process Arachidonate Secretion Establishment Of Localization In Cell Cellular Response To Antibiotic
Pathways			phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonate metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic
Drugs			Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone
Diseases
GWAS			Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)
Interacting Genes		31 interacting genes: ABI2 AIRIM BEX2 C19orf25 C1orf216 DRC4 EPS8 EXOC8 EXOSC5 FAM161B FAM9C FBXO44 FCHSD2 HAUS1 HGS KANK2 LNX1 MED21 MOS NDEL1 NTAQ1 OSTF1 PKNOX1 PLA2G4A RCOR3 RIBC1 SHPRH SPG21 TACC2 USHBP1 ZNF655	24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B
Entrez ID		54785	5321
HPRD ID		13368	08986
Ensembl ID		ENSG00000196544	ENSG00000116711
Uniprot IDs		Q96GS4	B4DZI4 P47712
PDB IDs			1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?			Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Defense Response Interleukin-18-mediated Signaling Pathway Response To Peptide Response To External Biotic Stimulus Response To Lipid Pyroptotic Inflammatory Response Response To Cytokine Protein Metabolic Process Regulation Of Inflammatory Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Response To Lipopolysaccharide Regulation Of Immune System Process Response To Muramyl Dipeptide Protein Kinase Activity Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Regulation Of Multicellular Organismal Process Interleukin-1-mediated Signaling Pathway Response To Mechanical Stimulus Inflammatory Response Protein Serine Kinase Activity Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Protein Phosphorylation Regulation Of Cell Adhesion Phagolysosome Phosphorylation Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Negative Regulation Of Multicellular Organismal Process Protein Catabolic Process Cellular Response To Oxygen-containing Compound Kinase Activity Apoptotic Process Cellular Response To Cytokine Stimulus Focal Adhesion Negative Regulation Of Protein Catabolic Process Response To Tumor Necrosis Factor Programmed Cell Death Cell Death NLRP1 Inflammasome Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Calcium-dependent Protein Serine/threonine Kinase Activity Response To Nicotine Protein Modification Process Cellular Response To Lipid Stress-induced Premature Senescence
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