PCSK4 and ASPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PCSK4	ASPH
Description		proprotein convertase subtilisin/kexin type 4	aspartate beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Acrosomal Membrane Trans-Golgi Network Membrane Cytoplasmic Vesicle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	Proteolysis Binding Of Sperm To Zona Pellucida Acrosome Reaction Fertilization Protein Processing Peptide Hormone Processing Reproductive Process Sperm Capacitation	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization
Pathways			Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs			Aspartic acid
Diseases
GWAS			Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)
Interacting Genes		3 interacting genes: ASPH FOXP1 IGF2	73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		54760	444
HPRD ID		06773	08996
Ensembl ID		ENSG00000115257	ENSG00000198363
Uniprot IDs		A0A140VJQ9 Q6UW60	B4DQ07 B7ZM96 G3XAN5 Q12797
PDB IDs			5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Regulation Of Organ Growth Negative Regulation Of Muscle Cell Differentiation Activation Of Store-operated Calcium Channel Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Cell Population Proliferation Regulation Of Muscle System Process Regulation Of Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Growth Regulation Of Developmental Growth Regulation Of Skeletal Muscle Tissue Growth Embryonic Placenta Morphogenesis Positive Regulation Of Interleukin-21 Production Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Osteoclast Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Cortical Endoplasmic Reticulum Positive Regulation Of B Cell Receptor Signaling Pathway Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Exocrine Pancreas Development Monocyte Activation Endothelial Cell Activation Positive Regulation Of Biosynthetic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Cellular Component Organization Regulation Of Calcium Ion Transport Into Cytosol Detection Of Calcium Ion Regulation Of System Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Striated Muscle Tissue Development Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Regulation Of Growth Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Insulin-like Growth Factor Receptor Binding Positive Regulation Of Skeletal Muscle Tissue Development Genomic Imprinting Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Defense Response To Bacterium Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Androgen Receptor Signaling Pathway Striatum Development Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Monocyte Differentiation T Follicular Helper Cell Differentiation	Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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