PCSK4 and IGF2

Number of citations of the paper that reports this interaction (PMID 16040806)
11

Data Source:
HPRD (in vitro)

		PCSK4	IGF2
Gene Name		proprotein convertase subtilisin/kexin type 4	insulin-like growth factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Receptor Activator Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Proteolysis Binding Of Sperm To Zona Pellucida Acrosome Reaction Sperm Capacitation	Skeletal System Development Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organismal Development Female Pregnancy Blood Coagulation Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Radiation Organ Morphogenesis Platelet Activation Exocrine Pancreas Development Response To Nutrient Levels Response To Estradiol Response To Nicotine Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Activated T Cell Proliferation Response To Drug Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Receptor Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways			IRS-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Response to elevated platelet cytosolic Ca2+ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R Platelet degranulation Platelet activation, signaling and aggregation IGF1R signaling cascade
Drugs
Diseases
GWAS			DNA methylation (variation) ( 23725790) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Prostate cancer ( 19767753)
Protein-Protein Interactions		1 interactors: IGF2	22 interactors: BAG6 FAF1 GPC3 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 NOV PCSK4 PLG RBPMS TF VTN WISP2
Entrez ID		54760	3481
HPRD ID		06773	00939
Ensembl ID		ENSG00000115257	ENSG00000167244
Uniprot IDs		B3KQ28 Q6UW60	P01344
PDB IDs			1GF2 1IGL 2L29 2V5P 3E4Z 3KR3
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Glycogen (starch) Synthase Activity Exocrine Pancreas Development Positive Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Genetic Imprinting Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Response To Nicotine Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Receptor Activity Exocrine System Development Positive Regulation Of Lipid Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Platelet Degranulation Regulation Of Steroid Biosynthetic Process Cellular Response To Mechanical Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of T Cell Proliferation Pancreas Development Regulation Of Steroid Metabolic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Regulation Of Mitotic Nuclear Division Response To Estradiol Memory Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of Lipid Biosynthetic Process Osteoblast Differentiation Response To Ethanol Glucose Metabolic Process Regulation Of T Cell Proliferation Response To Alkaloid Insulin Receptor Signaling Pathway	Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Carbohydrate Metabolic Process Regulation Of Cell Migration Regulation Of Phosphorylation Reproductive Process Regulation Of Cell Motility Exocrine Pancreas Development Exocrine System Development Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Response To Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Male Sex Determination Anatomical Structure Development Tissue Development Negative Regulation Of Smooth Muscle Cell Migration Protein Tetramerization Response To Insulin Response To Hormone Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase B Signaling
Tagcloud ?			affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane
Tagcloud (Difference) ?			affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane
Tagcloud (Intersection) ?