CTSA and TMEM154

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CTSA	TMEM154
Name		cathepsin A	transmembrane protein 154
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Lumenal Side Of Lysosomal Membrane	Membrane
	Molecular Function	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity Peptidase Activity Hydrolase Activity	Protein Binding
	Biological Process	Proteolysis Intracellular Protein Transport Regulation Of Protein Stability Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy	None
Pathways		MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism	None
Diseases		Galactosialidosis	None
GWAS		No GWAS studies recorded	Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821 ) Hip circumference ( 28552196 ) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507 ) Type 2 diabetes ( 24509480 28869590 29358691 30054458 30297969 30718926 32499647 )
Interacting Genes		46 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC10A6 SLC18A1 SLC30A2 SLC71A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2	11 interacting genes: CLCA4 CTSA CYB561D2 FUNDC2 FXYD6 GET3 GYPA MIP SGTA SLC35A4 SMIM1
Entrez ID		5476	201799
HPRD ID		02020	08719
Ensembl ID		ENSG00000064601	ENSG00000170006
Uniprot IDs		B4E324 P10619 X6R5C5 X6R8A1	Q6P9G4
PDB IDs		1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA	Not available
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Lumen Acetylcholine Receptor Regulator Activity Renal Water Transport Ganglioside Catabolic Process	Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Membrane Lumenal Side Of Lysosomal Membrane TRC Complex GET Complex Negative Regulation Of Chaperone-mediated Autophagy Ascorbate Homeostasis Negative Regulation Of Protein Catabolic Process BAT3 Complex Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity Serine-type Carboxypeptidase Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Ankyrin-1 Complex Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport Regulation Of Chaperone-mediated Autophagy Negative Regulation Of ERAD Pathway Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity