CTSA

Gene Name		cathepsin A
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Lysosome Endoplasmic Reticulum Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Intracellular Protein Transport Protein N-linked Glycosylation Via Asparagine Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Sphingolipid metabolism Defective ALG3 causes ALG3-CDG (CDG-1d) Glycosphingolipid metabolism Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: GLB1 LAMP2 NEU1
Entrez ID		5476
HPRD ID		02020
Ensembl ID		ENSG00000064601
Uniprot IDs		B4E324 P10619
PDB IDs		1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3
Enriched GO Terms of Interacting Partners?		Dolichol-linked Oligosaccharide Biosynthetic Process Glycosphingolipid Metabolic Process Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Glycolipid Metabolic Process Carbohydrate Catabolic Process Sphingolipid Metabolic Process Post-translational Protein Modification Membrane Lipid Metabolic Process Macromolecule Glycosylation Protein Glycosylation Glycosylation Galactose Catabolic Process Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Oligosaccharide Catabolic Process Keratan Sulfate Catabolic Process Galactose Metabolic Process Keratan Sulfate Metabolic Process Peptidyl-amino Acid Modification Cellular Lipid Metabolic Process Carbohydrate Metabolic Process Oligosaccharide Metabolic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Platelet Degranulation Protein Stabilization Catabolic Process Regulation Of Protein Stability Glycosaminoglycan Metabolic Process Platelet Activation Hexose Metabolic Process Pathogenesis Small Molecule Metabolic Process
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