CTSA and CSPG5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CTSA	CSPG5
Description		cathepsin A	chondroitin sulfate proteoglycan 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Lumenal Side Of Lysosomal Membrane	Golgi Membrane Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Lumen Plasma Membrane Cell Surface Membrane Golgi-associated Vesicle Membrane Lysosomal Lumen Synapse Postsynaptic Membrane Synaptic Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity Peptidase Activity Hydrolase Activity	Protein Binding Growth Factor Activity
	Biological Process	Proteolysis Intracellular Protein Transport Regulation Of Protein Stability Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy	Cytoskeleton Organization Signal Transduction Nervous System Development Cell Differentiation Intracellular Transport Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Synaptic Vesicle Exocytosis
Pathways		MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases		Galactosialidosis
GWAS			Body mass index ( 29273807) Smoking initiation ( 33082346)
Interacting Genes		46 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC10A6 SLC18A1 SLC30A2 SLC71A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2	3 interacting genes: CTSA ERBB3 GOPC
Entrez ID		5476	10675
HPRD ID		02020	08423
Ensembl ID		ENSG00000064601	ENSG00000114646
Uniprot IDs		B4E324 P10619 X6R5C5 X6R8A1	A0A087WUT8 B7Z2E0 O95196
PDB IDs		1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Lumen Acetylcholine Receptor Regulator Activity Renal Water Transport Ganglioside Catabolic Process	Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Neuregulin Receptor Activity Negative Regulation Of Chaperone-mediated Autophagy Lumenal Side Of Lysosomal Membrane Negative Regulation Of Anion Channel Activity ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Serine-type Carboxypeptidase Activity Schwann Cell Differentiation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Transport Negative Regulation Of Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Endocardial Cushion Development Negative Regulation Of Protein Localization To Cell Surface Regulation Of Monoatomic Anion Transport Golgi-associated Vesicle Membrane Apical Protein Localization Protein Tyrosine Kinase Activator Activity Molecular Sequestering Activity Trans-Golgi Network Transport Vesicle Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Striated Muscle Tissue Development ERBB2 Signaling Pathway Peripheral Nervous System Development Negative Regulation Of Transporter Activity Carboxypeptidase Activity Cranial Nerve Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Protein Localization To Cell Surface Regulation Of Striated Muscle Tissue Development Growth Factor Binding Regulation Of Muscle Organ Development Nerve Development Positive Regulation Of Calcium-mediated Signaling Mesenchyme Development Golgi To Plasma Membrane Transport Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Basal Plasma Membrane Lateral Plasma Membrane
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