CTSA and AHNAK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CTSA	AHNAK2
Description		cathepsin A	AHNAK nucleoprotein 2
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GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Lumenal Side Of Lysosomal Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane T-tubule Sarcolemma
	Molecular Function	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity Peptidase Activity Hydrolase Activity	Protein Binding
	Biological Process	Proteolysis Intracellular Protein Transport Regulation Of Protein Stability Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy	Regulation Of RNA Splicing
Pathways		MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism
Drugs
Diseases		Galactosialidosis
GWAS			Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 26663301 33272962)
Interacting Genes		46 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC10A6 SLC18A1 SLC30A2 SLC71A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2	16 interacting genes: ABLIM2 ASGR1 C3orf52 CTSA CYB5B CYBC1 FAM3C GABARAPL1 GABARAPL2 IGFBP5 PRAP1 SUMO2 TSPO2 UBIAD1 VAMP3 ZFPL1
Entrez ID		5476	113146
HPRD ID		02020	12261
Ensembl ID		ENSG00000064601	ENSG00000185567
Uniprot IDs		B4E324 P10619 X6R5C5 X6R8A1	Q8IVF2
PDB IDs		1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA	4CN0
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Lumen Acetylcholine Receptor Regulator Activity Renal Water Transport Ganglioside Catabolic Process	Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Phosphatidylethanolamine Binding GABA Receptor Binding Negative Regulation Of Skeletal Muscle Hypertrophy Beta-tubulin Binding Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Organelle Membrane Positive Regulation Of Triglyceride Transport 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Autophagosome Maturation Autophagosome Membrane
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