UGT1A1 and SEC23B

Number of citations of the paper that reports this interaction (PMID 9472029)
82

Data Source:
BioGRID (unspecified method)

		UGT1A1	SEC23B
Gene Name		UDP glucuronosyltransferase 1 family, polypeptide A1	Sec23 homolog B (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cytochrome Complex	Golgi Membrane Endoplasmic Reticulum Membrane Endomembrane System Membrane COPII Vesicle Coat Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Zinc Ion Binding
	Biological Process	Liver Development Porphyrin-containing Compound Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Acute-phase Response Response To Nutrient Digestion Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Biosynthetic Process Drug Metabolic Process Organ Regeneration Response To Lipopolysaccharide Cellular Response To Hormone Stimulus Heme Catabolic Process Response To Drug Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Cellular Glucuronidation	Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Vesicle-mediated Transport
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Heme degradation Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Metabolism of porphyrins Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Bilirubin levels ( 22085899 19419973 23371916 20639394 19414484) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Circulating cell-free DNA ( 22511988)
Protein-Protein Interactions		3 interactors: COPZ1 SEC23B UGDH	18 interactors: CPSF7 DTX2 FATE1 GALNT1 HOXA3 KDELR1 MAN2A1 PRRC1 SEC24C SEC24D SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 UGT1A1
Entrez ID		54658	10483
HPRD ID		08933	11543
Ensembl ID		ENSG00000242366	ENSG00000101310
Uniprot IDs		P22309 Q5DT03	B4DJW8 Q15437
PDB IDs
Enriched GO Terms of Interacting Partners?		UDP-glucuronate Biosynthetic Process Golgi Vesicle Transport UDP-glucuronate Metabolic Process COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding UDP-glucose Metabolic Process Cellular Glucuronidation Vesicle Targeting, To, From Or Within Golgi Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Gastrulation With Mouth Forming Second Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Cellular Protein Localization Membrane Budding Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport ER To Golgi Vesicle-mediated Transport Glycosaminoglycan Biosynthetic Process	Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting COPII Vesicle Coating COPII-coated Vesicle Budding Membrane Budding COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization ER To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Establishment Of Organelle Localization Organelle Localization Post-translational Protein Modification Cargo Loading Into Vesicle Golgi Organization Protein N-linked Glycosylation Via Asparagine Protein Glycosylation Macromolecule Glycosylation Protein N-linked Glycosylation Glycosylation Positive Regulation Of Viral Genome Replication Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Membrane Organization Protein Transport Vesicle-mediated Transport Intracellular Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Complex Assembly Organelle Organization Negative Regulation Of Viral Genome Replication Carbohydrate Metabolic Process Nuclear Speck Organization Biphenyl Catabolic Process Bilirubin Conjugation Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Transport Cellular Component Assembly Protein Localization Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Negative Regulation Of Viral Process Establishment Of Localization In Cell Cellular Protein Localization RNA Splicing
Tagcloud ?		24c 24t 388g 521c abc abcc2 abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn www	aflatoxin biogenesis btf3 calreticulin compartments confer dissected dynactin eef immunoblot nodules nucleolin nucleophosmin oncomine p450 participates peptidase pgrmc1 pur ribosome rough sec13 subcellular ter traffic transitional tripeptidyl unexpectedly usp10
Tagcloud (Difference) ?		24c 24t 388g 521c abc abcc2 abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn www	aflatoxin biogenesis btf3 calreticulin compartments confer dissected dynactin eef immunoblot nodules nucleolin nucleophosmin oncomine p450 participates peptidase pgrmc1 pur ribosome rough sec13 subcellular ter traffic transitional tripeptidyl unexpectedly usp10
Tagcloud (Intersection) ?