UGT1A1 and UGDH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		UGT1A1	UGDH
Gene Name		UDP glucuronosyltransferase 1 family, polypeptide A1	UDP-glucose 6-dehydrogenase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cytochrome Complex	Nucleoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity	UDP-glucose 6-dehydrogenase Activity Electron Carrier Activity NAD Binding
	Biological Process	Liver Development Porphyrin-containing Compound Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Acute-phase Response Response To Nutrient Digestion Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Biosynthetic Process Drug Metabolic Process Organ Regeneration Response To Lipopolysaccharide Cellular Response To Hormone Stimulus Heme Catabolic Process Response To Drug Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Cellular Glucuronidation	Gastrulation With Mouth Forming Second UDP-glucose Metabolic Process Glycosaminoglycan Biosynthetic Process UDP-glucuronate Biosynthetic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Cellular Glucuronidation Oxidation-reduction Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Heme degradation Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Metabolism of porphyrins Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Formation of the active cofactor, UDP-glucuronate Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			NADH
Diseases
GWAS		Bilirubin levels ( 22085899 19419973 23371916 20639394 19414484) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Circulating cell-free DNA ( 22511988)
Protein-Protein Interactions		3 interactors: COPZ1 SEC23B UGDH	3 interactors: AK5 RAD51 UGT1A1
Entrez ID		54658	7358
HPRD ID		08933	04535
Ensembl ID		ENSG00000242366	ENSG00000109814
Uniprot IDs		P22309 Q5DT03	O60701
PDB IDs			2Q3E 2QG4 3ITK 3KHU 3PRJ 3PTZ 3TDK 3TF5 4EDF
Enriched GO Terms of Interacting Partners?		UDP-glucuronate Biosynthetic Process Golgi Vesicle Transport UDP-glucuronate Metabolic Process COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding UDP-glucose Metabolic Process Cellular Glucuronidation Vesicle Targeting, To, From Or Within Golgi Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Gastrulation With Mouth Forming Second Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Cellular Protein Localization Membrane Budding Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport ER To Golgi Vesicle-mediated Transport Glycosaminoglycan Biosynthetic Process	Biphenyl Catabolic Process Bilirubin Conjugation DADP Biosynthetic Process Positive Regulation Of DNA Ligation Cellular Response To Camptothecin Response To Camptothecin Negative Regulation Of Cellular Glucuronidation DNA Recombinase Assembly Flavone Metabolic Process ADP Biosynthetic Process Cellular Response To Organic Cyclic Compound Heme Catabolic Process Xenobiotic Glucuronidation Cellular Response To Ethanol Deoxyribonucleoside Diphosphate Metabolic Process Biphenyl Metabolic Process Xenobiotic Catabolic Process Nucleoside Diphosphate Biosynthetic Process Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication ADP Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Flavonoid Biosynthetic Process Flavonoid Glucuronidation Cellular Glucuronidation Negative Regulation Of Steroid Metabolic Process Flavonoid Metabolic Process Regulation Of Double-strand Break Repair Estrogen Metabolic Process Retinoic Acid Metabolic Process Mitotic Recombination Response To Organic Cyclic Compound Drug Metabolic Process Nucleoside Diphosphate Phosphorylation Acute-phase Response Cellular Response To Alkaloid Heme Metabolic Process Reciprocal Meiotic Recombination Pyrimidine Ribonucleotide Biosynthetic Process Cellular Response To Glucocorticoid Stimulus Deoxyribonucleotide Metabolic Process Porphyrin-containing Compound Metabolic Process Cellular Response To Corticosteroid Stimulus Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Cellular Response To Ionizing Radiation Nucleoside Diphosphate Metabolic Process Regulation Of DNA Repair Heterocycle Metabolic Process
Tagcloud ?		24c 24t 388g 521c abc abcc2 abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn www	aldehyde breakdown bronsted c6 catalysis catalytic catalytically clarifies completes covalently crystallizing crystallographic cys deprotonates e161q gln glu glucuronic hydride hydrolysis incompetent nad nucleophile oxyanion succeeded thioester thiohemiacetal udp undergoes
Tagcloud (Difference) ?		24c 24t 388g 521c abc abcc2 abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn www	aldehyde breakdown bronsted c6 catalysis catalytic catalytically clarifies completes covalently crystallizing crystallographic cys deprotonates e161q gln glu glucuronic hydride hydrolysis incompetent nad nucleophile oxyanion succeeded thioester thiohemiacetal udp undergoes
Tagcloud (Intersection) ?