UGT1A1

Gene Name		UDP glucuronosyltransferase 1 family, polypeptide A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cytochrome Complex
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Liver Development Porphyrin-containing Compound Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Acute-phase Response Response To Nutrient Digestion Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Biosynthetic Process Drug Metabolic Process Organ Regeneration Response To Lipopolysaccharide Cellular Response To Hormone Stimulus Heme Catabolic Process Response To Drug Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Cellular Glucuronidation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Heme degradation Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Metabolism of porphyrins Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Bilirubin levels ( 22085899 19419973 23371916 20639394 19414484) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Circulating cell-free DNA ( 22511988)
Protein-protein Interactions		3 interactors: COPZ1 SEC23B UGDH
Entrez ID		54658
HPRD ID		08933
Ensembl ID		ENSG00000242366
Uniprot IDs		P22309 Q5DT03
PDB IDs
Enriched GO Terms of Interacting Partners?		UDP-glucuronate Biosynthetic Process Golgi Vesicle Transport UDP-glucuronate Metabolic Process COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding UDP-glucose Metabolic Process Cellular Glucuronidation Vesicle Targeting, To, From Or Within Golgi Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Gastrulation With Mouth Forming Second Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Cellular Protein Localization Membrane Budding Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport ER To Golgi Vesicle-mediated Transport Glycosaminoglycan Biosynthetic Process
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