UGT1A1 and COPZ1

Number of citations of the paper that reports this interaction (PMID 9472029)
82

Data Source:
BioGRID (unspecified method)

		UGT1A1	COPZ1
Gene Name		UDP glucuronosyltransferase 1 family, polypeptide A1	coatomer protein complex, subunit zeta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cytochrome Complex	Cytosol COPI Vesicle Coat
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Liver Development Porphyrin-containing Compound Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Acute-phase Response Response To Nutrient Digestion Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Biosynthetic Process Drug Metabolic Process Organ Regeneration Response To Lipopolysaccharide Cellular Response To Hormone Stimulus Heme Catabolic Process Response To Drug Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Cellular Glucuronidation	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Membrane Organization
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Heme degradation Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Metabolism of porphyrins Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	COPI Mediated Transport Golgi to ER Retrograde Transport
Drugs
Diseases
GWAS		Bilirubin levels ( 22085899 19419973 23371916 20639394 19414484) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Circulating cell-free DNA ( 22511988)	Mean platelet volume ( 22139419) Platelet counts ( 23263863)
Protein-Protein Interactions		3 interactors: COPZ1 SEC23B UGDH	7 interactors: APP COPA COPG1 COPG2 TMED10 TMED9 UGT1A1
Entrez ID		54658	22818
HPRD ID		08933	16738
Ensembl ID		ENSG00000242366	ENSG00000111481
Uniprot IDs		P22309 Q5DT03	B4DDX8 F8VS17 F8VWL5 P61923
PDB IDs			2HF6
Enriched GO Terms of Interacting Partners?		UDP-glucuronate Biosynthetic Process Golgi Vesicle Transport UDP-glucuronate Metabolic Process COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding UDP-glucose Metabolic Process Cellular Glucuronidation Vesicle Targeting, To, From Or Within Golgi Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Gastrulation With Mouth Forming Second Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Cellular Protein Localization Membrane Budding Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport ER To Golgi Vesicle-mediated Transport Glycosaminoglycan Biosynthetic Process	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Localization Within Membrane Vesicle Targeting Golgi Vesicle Transport Membrane Budding Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Vesicle-mediated Transport Intracellular Transport Establishment Of Organelle Localization Establishment Of Localization In Cell Organelle Localization Cellular Localization Membrane Organization Intracellular Protein Transport Golgi Organization Biphenyl Catabolic Process Bilirubin Conjugation Cellular Protein Localization Protein Transport Establishment Of Protein Localization Transport Digestion Synaptic Growth At Neuromuscular Junction Secretion Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Glucuronidation Protein Localization Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Flavone Metabolic Process Axon Choice Point Recognition Establishment Of Golgi Localization Pancreatic Juice Secretion Heme Catabolic Process Steroid Metabolic Process Xenobiotic Glucuronidation Cargo Loading Into Vesicle Neuron Remodeling Cellular Response To Ethanol Biphenyl Metabolic Process Xenobiotic Catabolic Process
Tagcloud ?		24c 24t 388g 521c abc abcc2 abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn www	atpases cgr cognate copa copb copper copz2 corynebacterium csor derepression efflux encode exporter glutamicum implied lacz metallochaperone monocistronic multilayered nickel operon redundant regulon repressor talk uniquely zinc zur
Tagcloud (Difference) ?		24c 24t 388g 521c abc abcc2 abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn www	atpases cgr cognate copa copb copper copz2 corynebacterium csor derepression efflux encode exporter glutamicum implied lacz metallochaperone monocistronic multilayered nickel operon redundant regulon repressor talk uniquely zinc zur
Tagcloud (Intersection) ?