PPA1 and MCPH1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
54

Data Source:
BioGRID (two hybrid)

		PPA1	MCPH1
Description		inorganic pyrophosphatase 1	microcephalin 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Cytoplasm Centrosome Cytoskeleton
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphate Phosphatase Activity Pyrophosphatase Activity Hydrolase Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Phosphate-containing Compound Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Regulation Of Gene Expression Cerebral Cortex Development Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance
Pathways		Cytosolic tRNA aminoacylation Pyrophosphate hydrolysis	Condensation of Prophase Chromosomes
Drugs
Diseases			Primary microcephaly (MCPH)
GWAS			Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		11 interacting genes: CEBPA ERBB2 HSPB1 MCPH1 MTRNR2L1 SETDB1 SUMO4 TP53 UBC UNC119 WIPI1	71 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CFTR CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DMC1 DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RAD51 RBM39 RSL24D1 RUVBL2 S100A16 SKIC8 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR73 WDR75 WNT10B ZMIZ2
Entrez ID		5464	79648
HPRD ID		01527	06174
Ensembl ID		ENSG00000180817	ENSG00000147316
Uniprot IDs		Q15181 V9HWB5	A0A8I5KPV6 A0A8I5KR64 A0A8I5KR97 A0A8I5KV10 A0A8I5KW78 A0A8I5KZ89 Q8NEM0
PDB IDs		6C45 7BTN 7CMO 8J7Q	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Initiation Generation Of Precursor Metabolites And Energy RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Heterodimerization Activity Negative Regulation Of Cell Development Response To Vitamin B2 Regulation Of Metabolic Process C/EBP Complex Regulation Of Protein Metabolic Process RNA Polymerase I Core Binding Protein Localization To Synapse Regulation Of Phosphorus Metabolic Process ERBB3:ERBB2 Complex Intracellular Protein Localization Regulation Of Protein Phosphorylation Protein Localization To Cell Junction T Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Receptor Tyrosine Kinase Binding Endosome Membrane Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Regulation Of Autophagy Cytoskeleton Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Promoter-specific Chromatin Binding Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Protein Tag Activity Negative Regulation Of Caveolin-mediated Endocytosis Vesicle Targeting, Trans-Golgi To Endosome Chromatin Binding Negative Regulation Of Hemopoiesis	Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Regulation Of DNA Repair Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Recombination Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Cellular Response To Gamma Radiation Protein Stabilization DNA Recombination Single-stranded DNA Binding Regulation Of Chromosome Organization Regulation Of Metabolic Process DNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly DNA Strand Exchange Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Positive Regulation Of Macromolecule Metabolic Process Recombinational Repair Replicative Senescence Cytosol DNA Replication RNA Binding DNA Replication Origin Binding ATP Binding Double-strand Break Repair Regulation Of Macromolecule Biosynthetic Process DNA Repair Histone H2AXS139 Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Macromolecule Metabolic Process Single-stranded DNA Helicase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Chromatin Remodeling
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