PPA1 and WIPI1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PPA1	WIPI1
Gene Name		pyrophosphatase (inorganic) 1	WD repeat domain, phosphoinositide interacting 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Golgi Membrane Pre-autophagosomal Structure Autophagic Vacuole Membrane Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Endosome Membrane Extrinsic Component Of Membrane Clathrin-coated Vesicle Pre-autophagosomal Structure Membrane
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphatase Activity	Receptor Binding Estrogen Receptor Binding Phosphatidylinositol-3-phosphate Binding Androgen Receptor Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Phosphate-containing Compound Metabolic Process Gene Expression Diphosphate Metabolic Process	Autophagic Vacuole Assembly Mitochondrion Degradation Protein Lipidation Autophagy Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Unfolded Protein Response Protein Localization To Pre-autophagosomal Structure Cellular Protein Metabolic Process Nucleophagy Vesicle Targeting, Trans-Golgi To Endosome
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: HSPB1 MTRNR2L1 SETDB1 SUMO4 TP53 UNC119 WIPI1	5 interactors: AR ESR1 ESR2 KCTD15 PPA1
Entrez ID		5464	55062
HPRD ID		01527	08540
Ensembl ID		ENSG00000180817	ENSG00000070540
Uniprot IDs		Q15181	G5EA37 Q5MNZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis ER-nucleus Signaling Pathway Response To Unfolded Protein Response To External Stimulus Negative Regulation Of Macromitophagy Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Vesicle Targeting, Trans-Golgi To Endosome Cellular Response To Starvation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Response To Endoplasmic Reticulum Stress Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Response To Nutrient Levels Response To Starvation Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Extracellular Stimulus Regulation Of Catalytic Activity Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Mitochondrial DNA Repair Regulation Of Caveolin-mediated Endocytosis Peptidyl-lysine Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Mitotic Cytokinetic Process Glial Cell Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Chemotaxis Oxidative Stress-induced Premature Senescence Protein Localization To Pre-autophagosomal Structure Histone H3-K9 Trimethylation ER Overload Response Homotypic Cell-cell Adhesion	Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Vagina Development Uterus Development Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Estrogen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Female Genitalia Development DNA-templated Transcription, Initiation Sex Differentiation Prostate Gland Epithelium Morphogenesis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Prostate Gland Morphogenesis Urogenital System Development Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Genitalia Development Response To Steroid Hormone Ovarian Follicle Development Gland Development Reproductive Structure Development Reproductive System Development Cellular Response To Hormone Stimulus Ovulation Cycle Process Female Gonad Development Negative Regulation Of Integrin Biosynthetic Process Ovulation Cycle Development Of Primary Female Sexual Characteristics Developmental Process Involved In Reproduction Diphosphate Metabolic Process Response To Lipid Gland Morphogenesis Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Integrin Biosynthetic Process Prostate Epithelial Cord Elongation Epithelial Cell Development Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signal Transduction Gonad Development Development Of Primary Sexual Characteristics Epithelial Cell Maturation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway
Tagcloud ?			28c atg16l autophagic autophagosome autophagy carbonyl coa desaturase dimethylamino earliest immunoblot lc3 microscopic n2 n5 oleic p62 puncta pyridinedicarboxamide rapamycin scd scd1 sqstm1 starvation stearoyl structurally thiazolyl ulk1 unsaturated
Tagcloud (Difference) ?			28c atg16l autophagic autophagosome autophagy carbonyl coa desaturase dimethylamino earliest immunoblot lc3 microscopic n2 n5 oleic p62 puncta pyridinedicarboxamide rapamycin scd scd1 sqstm1 starvation stearoyl structurally thiazolyl ulk1 unsaturated
Tagcloud (Intersection) ?