PPA1 and WIPI1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PPA1	WIPI1
Description		inorganic pyrophosphatase 1	WD repeat domain, phosphoinositide interacting 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Golgi Membrane Phagophore Assembly Site Autophagosome Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Endosome Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Phagophore Assembly Site Membrane
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphate Phosphatase Activity Pyrophosphatase Activity Hydrolase Activity Metal Ion Binding	Signaling Receptor Binding Protein Binding Lipid Binding Nuclear Estrogen Receptor Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding Nuclear Androgen Receptor Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Phosphate-containing Compound Metabolic Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Vesicle Targeting, Trans-Golgi To Endosome Glycophagy Positive Regulation Of Autophagosome Assembly
Pathways		Cytosolic tRNA aminoacylation Pyrophosphate hydrolysis	Macroautophagy XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS			HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		11 interacting genes: CEBPA ERBB2 HSPB1 MCPH1 MTRNR2L1 SETDB1 SUMO4 TP53 UBC UNC119 WIPI1	5 interacting genes: AR ESR1 ESR2 KCTD15 PPA1
Entrez ID		5464	55062
HPRD ID		01527	08540
Ensembl ID		ENSG00000180817	ENSG00000070540
Uniprot IDs		Q15181 V9HWB5	B4DX63 G5EA37 Q5MNZ9
PDB IDs		6C45 7BTN 7CMO 8J7Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Initiation Generation Of Precursor Metabolites And Energy RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Heterodimerization Activity Negative Regulation Of Cell Development Response To Vitamin B2 Regulation Of Metabolic Process C/EBP Complex Regulation Of Protein Metabolic Process RNA Polymerase I Core Binding Protein Localization To Synapse Regulation Of Phosphorus Metabolic Process ERBB3:ERBB2 Complex Intracellular Protein Localization Regulation Of Protein Phosphorylation Protein Localization To Cell Junction T Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Receptor Tyrosine Kinase Binding Endosome Membrane Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Regulation Of Autophagy Cytoskeleton Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Promoter-specific Chromatin Binding Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Protein Tag Activity Negative Regulation Of Caveolin-mediated Endocytosis Vesicle Targeting, Trans-Golgi To Endosome Chromatin Binding Negative Regulation Of Hemopoiesis	Estrogen Response Element Binding Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Nuclear Receptor Activity Nuclear Estrogen Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Prostate Gland Growth Hormone-mediated Signaling Pathway Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Prostate Gland Epithelium Morphogenesis Intracellular Receptor Signaling Pathway Cellular Response To Estradiol Stimulus Lipid Binding Organ Growth Transcription Coactivator Binding Regulation Of Morphogenesis Of A Branching Structure Enzyme Binding Response To Estrogen Negative Regulation Of DNA-templated Transcription Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Cellular Response To Lipid Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process ATPase Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Induction Male Somatic Sex Determination Beta-catenin Binding Male Gonad Development Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Gonad Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Response To Lipid Epithelial Cell Proliferation Regulation Of Reproductive Process Male Genitalia Morphogenesis
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