PPA1 and HSPB1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPA1	HSPB1
Gene Name		pyrophosphatase (inorganic) 1	heat shock 27kDa protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphatase Activity	Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Ubiquitin Binding Poly(A) RNA Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Phosphate-containing Compound Metabolic Process Gene Expression Diphosphate Metabolic Process	Retina Homeostasis Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Movement Of Cell Or Subcellular Component Response To Unfolded Protein Response To Virus Gene Expression Positive Regulation Of Interleukin-1 Beta Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Regulation of mRNA stability by proteins that bind AU-rich elements Signaling by VEGF AUF1 (hnRNP D0) destabilizes mRNA VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: HSPB1 MTRNR2L1 SETDB1 SUMO4 TP53 UNC119 WIPI1	40 interactors: ACTC1 AKT1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX EFTUD2 EIF4G1 HNRNPD HSPB8 IGSF21 INS LBP LRIF1 MAPKAPK2 MAPKAPK3 MAPKAPK5 MED31 MFAP1 NFKBIA PLG POP7 PPA1 PPM1A PRKD1 PRPF19 RBM48 RPS6KA5 SERTAD1 SF3B3 SMARCD1 SNCA TGFB1I1 TGM1 TP53 UCHL5 WDR83
Entrez ID		5464	3315
HPRD ID		01527	09076
Ensembl ID		ENSG00000180817	ENSG00000106211
Uniprot IDs		Q15181	P04792
PDB IDs			3Q9P 3Q9Q
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis ER-nucleus Signaling Pathway Response To Unfolded Protein Response To External Stimulus Negative Regulation Of Macromitophagy Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Vesicle Targeting, Trans-Golgi To Endosome Cellular Response To Starvation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Response To Endoplasmic Reticulum Stress Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Response To Nutrient Levels Response To Starvation Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Extracellular Stimulus Regulation Of Catalytic Activity Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Mitochondrial DNA Repair Regulation Of Caveolin-mediated Endocytosis Peptidyl-lysine Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Mitotic Cytokinetic Process Glial Cell Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Chemotaxis Oxidative Stress-induced Premature Senescence Protein Localization To Pre-autophagosomal Structure Histone H3-K9 Trimethylation ER Overload Response Homotypic Cell-cell Adhesion	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of Transport Positive Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Peptidyl-serine Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Organic Substance Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Reactive Oxygen Species Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Intracellular Transport MyD88-dependent Toll-like Receptor Signaling Pathway Gene Expression
Tagcloud ?			adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Difference) ?			adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Intersection) ?