ING3 and NR1H3

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ING3	NR1H3
Description		inhibitor of growth family member 3	nuclear receptor subfamily 1 group H member 3
Image
GO Annotations	Cellular Component	Nucleosome Swr1 Complex Nucleus Nucleoplasm Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Zinc Ion Binding Histone H4 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H2A Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Histone H3K4me3 Reader Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Chromatin DNA Binding Sterol Response Element Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Lipid Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm MRNA Transcription By RNA Polymerase II Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		HATs acetylate histones	PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
Diseases
GWAS			Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood glucose levels ( 31928498) Creatinine levels ( 29403010) Feeling miserable ( 29500382) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 20686565 19060910) Hypertension ( 31879980) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 27863252) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 27863252) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Triglyceride levels ( 32154731) Triglycerides ( 30275531)
Interacting Genes		9 interacting genes: APP BEX5 FBXO25 NR1H2 NR1H3 SIVA1 TEX11 TRIM54 USHBP1	35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC
Entrez ID		54556	10062
HPRD ID		06321	07211
Ensembl ID		ENSG00000071243	ENSG00000025434
Uniprot IDs		B7ZKQ7 Q9NXR8	B4DXU5 B5MBY7 F1D8N1 Q13133
PDB IDs		1X4I 7ZMX	1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Phosphatidylcholine Acyl-chain Remodeling Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cholesterol Efflux Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Lipid Storage Regulation Of Fatty Acid Biosynthetic Process MRNA Transcription By RNA Polymerase II Regulation Of Cholesterol Efflux Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress Nuclear Receptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway MRNA Transcription Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Secretion Of Lysosomal Enzymes CD27 Receptor Binding Meiotic Gene Conversion Putamen Development Caudate Nucleus Development Phosphatidylcholine Metabolic Process Regulation Of Endocytosis Regulation Of Cholesterol Transport Negative Regulation Of Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Transport Acetylcholine Receptor Activator Activity Regulation Of MiRNA Metabolic Process Metal Ion Binding Regulation Of Proteolysis	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Receptor Activity Hormone-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Chromatin Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Metabolic Process Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Retinoid X Receptor Binding Nucleoplasm RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Retinoic Acid-responsive Element Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Programmed Cell Death Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Regulation Of Lipid Metabolic Process Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process
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