POU3F3 and PPP1R15A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		POU3F3	PPP1R15A
Gene Name		POU class 3 homeobox 3	protein phosphatase 1, regulatory subunit 15A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding HMG Box Domain Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Regulator Activity Protein Kinase Binding Protein Phosphatase Type 1 Activator Activity
	Biological Process	Transcription, DNA-templated Central Nervous System Development Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Metanephric Ascending Thin Limb Development Metanephric Macula Densa Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Metanephric DCT Cell Differentiation	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		5 interactors: POU3F4 PPP1R15A SOX10 SOX11 SOX8	16 interactors: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		5455	23645
HPRD ID		03922	06572
Ensembl ID			ENSG00000087074
Uniprot IDs		P20264	O75807
PDB IDs
Enriched GO Terms of Interacting Partners?		Autonomic Nervous System Development Neural Crest Cell Development Oligodendrocyte Differentiation Neural Crest Cell Differentiation Regulation Of Gliogenesis Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Glial Cell Differentiation Mesenchyme Development Transcription From RNA Polymerase II Promoter Gliogenesis Stem Cell Development Central Nervous System Development Negative Regulation Of Cell Death Stem Cell Differentiation Embryo Development Neuroepithelial Cell Differentiation Neural Crest Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Positive Regulation Of Gliogenesis Tube Morphogenesis Skeletal Muscle Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Gene Expression Regulation Of Cell Death Generation Of Neurons Positive Regulation Of Cell Development Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Epithelial Cell Differentiation Neurogenesis Sensory Organ Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Morphogenesis Peripheral Nervous System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Lens Epithelial Cell Proliferation Positive Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hippo Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Proliferation Regulation Of RNA Metabolic Process Regulation Of Neurogenesis Tube Development Negative Regulation Of Cellular Metabolic Process Camera-type Eye Morphogenesis	Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Protein Refolding Gene Expression Viral Genome Replication Blood Coagulation Cell Division Hemostasis Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Viral Life Cycle Regulation Of Cellular Process Platelet Activation Cellular Metabolic Process B Cell Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Body Fluid Levels Wound Healing Cellular Response To Stimulus Positive Regulation Of Oligodendrocyte Progenitor Proliferation Metanephric Macula Densa Development Metanephric DCT Cell Differentiation Positive Regulation Of Cellular Response To Drug Negative Regulation Of Mast Cell Proliferation Glycogen Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Response To Wounding Platelet Degranulation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Heat Acclimation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Polysaccharide Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		aberrantly affiliate colonies densely dnmt dnmt3a dnmt3b eca escc guangzhou hairpin hypermethylated intergenic islands knocked lentiviral linc lincrna lincrnas neighboring noncoding nontumor pharmacologic rnas slowly soochow te thousands tylectomy	ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic
Tagcloud (Difference) ?		aberrantly affiliate colonies densely dnmt dnmt3a dnmt3b eca escc guangzhou hairpin hypermethylated intergenic islands knocked lentiviral linc lincrna lincrnas neighboring noncoding nontumor pharmacologic rnas slowly soochow te thousands tylectomy	ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic
Tagcloud (Intersection) ?