POU3F3 and SOX10

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (two hybrid, in vitro)

		POU3F3	SOX10
Gene Name		POU class 3 homeobox 3	SRY (sex determining region Y)-box 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Extrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding HMG Box Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Transcription, DNA-templated Central Nervous System Development Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Metanephric Ascending Thin Limb Development Metanephric Macula Densa Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Metanephric DCT Cell Differentiation	In Utero Embryonic Development Neural Crest Cell Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gliogenesis Melanocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		5 interactors: POU3F4 PPP1R15A SOX10 SOX11 SOX8	28 interactors: ALX4 CDK6 CEBPA DLX5 EGR2 EXOC5 HHEX HIVEP1 HOXA3 HOXC4 JUN MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1
Entrez ID		5455	6663
HPRD ID		03922	03752
Ensembl ID			ENSG00000100146
Uniprot IDs		P20264	B4DV62 P56693
PDB IDs
Enriched GO Terms of Interacting Partners?		Autonomic Nervous System Development Neural Crest Cell Development Oligodendrocyte Differentiation Neural Crest Cell Differentiation Regulation Of Gliogenesis Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Glial Cell Differentiation Mesenchyme Development Transcription From RNA Polymerase II Promoter Gliogenesis Stem Cell Development Central Nervous System Development Negative Regulation Of Cell Death Stem Cell Differentiation Embryo Development Neuroepithelial Cell Differentiation Neural Crest Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Positive Regulation Of Gliogenesis Tube Morphogenesis Skeletal Muscle Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Gene Expression Regulation Of Cell Death Generation Of Neurons Positive Regulation Of Cell Development Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Epithelial Cell Differentiation Neurogenesis Sensory Organ Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Morphogenesis Peripheral Nervous System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Lens Epithelial Cell Proliferation Positive Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hippo Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Proliferation Regulation Of RNA Metabolic Process Regulation Of Neurogenesis Tube Development Negative Regulation Of Cellular Metabolic Process Camera-type Eye Morphogenesis	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Tissue Development Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process System Development Macromolecule Biosynthetic Process Protein Sumoylation Embryonic Morphogenesis Anatomical Structure Development Embryonic Organ Development Embryo Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Cellular Nitrogen Compound Metabolic Process Pattern Specification Process Embryonic Organ Morphogenesis Organ Morphogenesis Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Cell Proliferation Gland Development
Tagcloud ?		aberrantly affiliate colonies densely dnmt dnmt3a dnmt3b eca escc guangzhou hairpin hypermethylated intergenic islands knocked lentiviral linc lincrna lincrnas neighboring noncoding nontumor pharmacologic rnas slowly soochow te thousands tylectomy	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally specification stationary temporally unexpected
Tagcloud (Difference) ?		aberrantly affiliate colonies densely dnmt dnmt3a dnmt3b eca escc guangzhou hairpin hypermethylated intergenic islands knocked lentiviral linc lincrna lincrnas neighboring noncoding nontumor pharmacologic rnas slowly soochow te thousands tylectomy	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally specification stationary temporally unexpected
Tagcloud (Intersection) ?