POU3F3 and SOX8

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (two hybrid)

		POU3F3	SOX8
Gene Name		POU class 3 homeobox 3	SRY (sex determining region Y)-box 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding HMG Box Domain Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Factor Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Central Nervous System Development Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Metanephric Ascending Thin Limb Development Metanephric Macula Densa Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Metanephric DCT Cell Differentiation	Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways
Drugs
Diseases
GWAS		Response to taxane treatment (docetaxel) ( 23006423)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		5 interactors: POU3F4 PPP1R15A SOX10 SOX11 SOX8	18 interactors: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		5455	30812
HPRD ID		03922	16175
Ensembl ID			ENSG00000005513
Uniprot IDs		P20264	P57073
PDB IDs
Enriched GO Terms of Interacting Partners?		Autonomic Nervous System Development Neural Crest Cell Development Oligodendrocyte Differentiation Neural Crest Cell Differentiation Regulation Of Gliogenesis Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Glial Cell Differentiation Mesenchyme Development Transcription From RNA Polymerase II Promoter Gliogenesis Stem Cell Development Central Nervous System Development Negative Regulation Of Cell Death Stem Cell Differentiation Embryo Development Neuroepithelial Cell Differentiation Neural Crest Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Positive Regulation Of Gliogenesis Tube Morphogenesis Skeletal Muscle Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Gene Expression Regulation Of Cell Death Generation Of Neurons Positive Regulation Of Cell Development Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Epithelial Cell Differentiation Neurogenesis Sensory Organ Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Morphogenesis Peripheral Nervous System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Lens Epithelial Cell Proliferation Positive Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hippo Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Proliferation Regulation Of RNA Metabolic Process Regulation Of Neurogenesis Tube Development Negative Regulation Of Cellular Metabolic Process Camera-type Eye Morphogenesis	Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Cell Differentiation Tissue Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Liver Development Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Embryonic Organ Development Positive Regulation By Host Of Viral Transcription Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Heart Development Endoderm Development
Tagcloud ?		aberrantly affiliate colonies densely dnmt dnmt3a dnmt3b eca escc guangzhou hairpin hypermethylated intergenic islands knocked lentiviral linc lincrna lincrnas neighboring noncoding nontumor pharmacologic rnas slowly soochow te thousands tylectomy	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Difference) ?		aberrantly affiliate colonies densely dnmt dnmt3a dnmt3b eca escc guangzhou hairpin hypermethylated intergenic islands knocked lentiviral linc lincrna lincrnas neighboring noncoding nontumor pharmacologic rnas slowly soochow te thousands tylectomy	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Intersection) ?