HSPA4 and STIP1

Number of citations of the paper that reports this interaction (PubMedID 23938469)
66

Data Source:
BioGRID (two hybrid)

		HSPA4	STIP1
Description		heat shock protein family A (Hsp70) member 4	stress induced phosphoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Organelle Extracellular Exosome	Nucleus Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Protein Folding Chaperone Complex Dynein Axonemal Particle
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding ATP-dependent Protein Folding Chaperone	RNA Binding Protein Binding Hsp90 Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Protein Import Into Mitochondrial Matrix Chaperone-mediated Protein Complex Assembly	Cellular Response To Interleukin-7
Pathways		Regulation of HSF1-mediated heat shock response	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RND1 GTPase cycle
Drugs		Phenethyl Isothiocyanate	Copper
Diseases
GWAS		A body shape index ( 34021172) Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 31928498 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) Monocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		72 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BRMS1 CALM1 CD40 CDC73 CDKN2A CEBPA CSNK1A1 CSNK2A1 DDIT4 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSF2 HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STIP1 STK4 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A	35 interacting genes: ACD ACVR1 AIP APP CBX4 CDC37 CHD3 CLCN1 CLK1 EGFR ERBB2 FEZ2 FKBP5 HIPK2 HSP90AA1 HSPA14 HSPA1A HSPA4 HSPA8 LAMB2 LMO2 MAGED4 MAP3K8 OGT PIAS2 PIAS3 PIAS4 POT1 PRNP PTGES3 RASGRF1 SUMO2 SUMO4 UBE2I UBR5
Entrez ID		3308	10963
HPRD ID		09025	05454
Ensembl ID		ENSG00000170606	ENSG00000168439
Uniprot IDs		P34932	P31948 V9HW72
PDB IDs			1ELR 1ELW 2LNI 2NC9 3ESK 3FWV 7KW7
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cytosol Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Response To Lipid Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway	SUMO Transferase Activity Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein Folding ATP-dependent Protein Folding Chaperone SUMO Ligase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription PML Body Chaperone-mediated Protein Complex Assembly Unfolded Protein Binding Telomere Maintenance Via Telomerase Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process RNA-templated DNA Biosynthetic Process Heat Shock Protein Binding Protein Refolding Negative Regulation Of RNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA-templated Transcription Protein Folding Chaperone Complex Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Signal Transduction Regulation Of Telomere Maintenance Via Telomerase Protein-folding Chaperone Binding ATP Binding Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Folding Chaperone Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling
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