HSPA4 and DDIT4

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPA4	DDIT4
Description		heat shock protein family A (Hsp70) member 4	DNA damage inducible transcript 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Organelle Extracellular Exosome	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding ATP-dependent Protein Folding Chaperone	Protein Binding 14-3-3 Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Protein Import Into Mitochondrial Matrix Chaperone-mediated Protein Complex Assembly	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Signal Transduction Neuron Differentiation Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process
Pathways		Regulation of HSF1-mediated heat shock response	TP53 Regulates Metabolic Genes
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		A body shape index ( 34021172) Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 31928498 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324) Refractive error ( 32231278)
Interacting Genes		72 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BRMS1 CALM1 CD40 CDC73 CDKN2A CEBPA CSNK1A1 CSNK2A1 DDIT4 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSF2 HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STIP1 STK4 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A	8 interacting genes: GSK3B HSPA4 HSPB2 HUWE1 LRIF1 LRRK2 PDPK1 TXNIP
Entrez ID		3308	54541
HPRD ID		09025	09662
Ensembl ID		ENSG00000170606	ENSG00000168209
Uniprot IDs		P34932	Q9NX09
PDB IDs			3LQ9 7MOP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cytosol Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Response To Lipid Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Post-translational Protein Modification Wnt Signalosome Protein Autophosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Regulation Of Post-translational Protein Modification Protein Localization To Mitochondrion Regulation Of Apoptotic Process Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Membrane Permeability Protein Serine Kinase Activity Intracellular Signaling Cassette Protein Phosphorylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Negative Regulation Of Programmed Cell Death Establishment Of Protein Localization To Organelle 3-phosphoinositide-dependent Protein Kinase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Autophagy Positive Regulation Of Protein Modification Process Phosphorylation Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Superior Temporal Gyrus Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Unfolded Protein
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