DDX4 and SPSB2

Number of citations of the paper that reports this interaction (PubMedID 20561531)
36

Data Source:
BioGRID (unspecified method)

		DDX4	SPSB2
Description		DEAD-box helicase 4	splA/ryanodine receptor domain and SOCS box containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Helicase Activity MRNA Binding Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Molecular Condensate Scaffold Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Gamete Generation Germ Cell Development Spermatogenesis Cell Differentiation Flagellated Sperm Motility Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		PIWI-interacting RNA (piRNA) biogenesis RND3 GTPase cycle	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)	Colorectal cancer ( 26965516) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4	11 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PRMT1 RECK SMARCD1 TRIM55 TRIM63
Entrez ID		54514	84727
HPRD ID		05593	13610
Ensembl ID		ENSG00000152670	ENSG00000111671
Uniprot IDs		Q9NQI0	Q99619
PDB IDs			3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinucleolar Chromocenter Regulation Of Circadian Rhythm Positive Regulation Of Meiosis I Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Secondary PiRNA Processing PET Complex Positive Regulation Of Protein Metabolic Process Transposable Element Silencing By MRNA Destabilization PiRNA-mediated Gene Silencing By MRNA Destabilization Post-translational Protein Modification Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Regulation Of Meiosis I Germ-line Stem Cell Population Maintenance Dense Body PiRNA Binding Macromolecule Catabolic Process Rhythmic Process Pi-body Proteolysis Transposable Element Silencing By PiRNA-mediated DNA Methylation Chromatoid Body Negative Regulation Of Circadian Rhythm Positive Regulation Of Meiotic Nuclear Division PiRNA Processing Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Protein Polyubiquitination P Granule Regulation Of Protein Metabolic Process Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Meiotic Cell Cycle Protein Modification Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Polyubiquitination Microtubule Nucleation Regulation Of Meiotic Nuclear Division Microtubule Associated Complex RNA Endonuclease Activity Regulation Of Cytoplasmic Translation DNA Methylation-dependent Constitutive Heterochromatin Formation Cytoplasm	Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Innate Immune Response Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cellular Response To Oxygen-containing Compound Chromatin Organization Epigenetic Regulation Of Gene Expression Defense Response To Symbiont Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Defense Response To Other Organism Positive Regulation Of Interleukin-6 Production Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Double-strand Break Repair GATOR1 Complex Binding Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of Establishment Of Blood-brain Barrier Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Peptidase Inhibitor Activity Growth Factor Receptor Binding
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