DDX4 and PIWIL2

Number of citations of the paper that reports this interaction (PubMedID 14736746)
0

Data Source:
HPRD (in vivo, in vitro)

		DDX4	PIWIL2
Description		DEAD-box helicase 4	piwi like RNA-mediated gene silencing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body	Nucleus Cytoplasm Perinucleolar Chromocenter Chromatoid Body P Granule Pi-body Dense Body PET Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Helicase Activity MRNA Binding Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Molecular Condensate Scaffold Activity	Nucleic Acid Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Gamete Generation Germ Cell Development Spermatogenesis Cell Differentiation Flagellated Sperm Motility Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation	Regulation Of Translation Spermatogenesis Cell Differentiation Germ-line Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Negative Regulation Of Circadian Rhythm Oogenesis Rhythmic Process Meiotic Cell Cycle Positive Regulation Of Meiosis I Secondary PiRNA Processing PiRNA-mediated Gene Silencing By MRNA Destabilization Transposable Element Silencing By Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By MRNA Destabilization Transposable Element Silencing By PiRNA-mediated DNA Methylation Positive Regulation Of Cytoplasmic Translation
Pathways		PIWI-interacting RNA (piRNA) biogenesis RND3 GTPase cycle	PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)	Hypertriglyceridemia ( 23505323)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4	5 interacting genes: DDX4 DICER1 KRT8 RNF10 TBCB
Entrez ID		54514	55124
HPRD ID		05593	11434
Ensembl ID		ENSG00000152670	ENSG00000197181
Uniprot IDs		Q9NQI0	Q8TC59 W0HK13
PDB IDs			3O7X 3QIR 7YFX
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinucleolar Chromocenter Regulation Of Circadian Rhythm Positive Regulation Of Meiosis I Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Secondary PiRNA Processing PET Complex Positive Regulation Of Protein Metabolic Process Transposable Element Silencing By MRNA Destabilization PiRNA-mediated Gene Silencing By MRNA Destabilization Post-translational Protein Modification Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Regulation Of Meiosis I Germ-line Stem Cell Population Maintenance Dense Body PiRNA Binding Macromolecule Catabolic Process Rhythmic Process Pi-body Proteolysis Transposable Element Silencing By PiRNA-mediated DNA Methylation Chromatoid Body Negative Regulation Of Circadian Rhythm Positive Regulation Of Meiotic Nuclear Division PiRNA Processing Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Protein Polyubiquitination P Granule Regulation Of Protein Metabolic Process Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Meiotic Cell Cycle Protein Modification Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Polyubiquitination Microtubule Nucleation Regulation Of Meiotic Nuclear Division Microtubule Associated Complex RNA Endonuclease Activity Regulation Of Cytoplasmic Translation DNA Methylation-dependent Constitutive Heterochromatin Formation Cytoplasm	Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Regulatory RNA Binding Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Helicase Activity Peripheral Nervous System Myelin Formation Negative Regulation Of Nervous System Development Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Regulatory NcRNA-mediated Gene Silencing Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell Development RISC-loading Complex SiRNA Processing Pi-body Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding Tubulin Complex Assembly RISC Complex Assembly SiRNA Binding TRNA Decay Apoptotic DNA Fragmentation Transposable Element Silencing By PiRNA-mediated DNA Methylation Pre-miRNA Processing Regulation Of Neurogenesis Myelin Assembly Hepatocyte Apoptotic Process PiRNA Processing P Granule Microtubule Plus-end Binding Regulation Of Nervous System Development Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development MiRNA Metabolic Process
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