DDX4

Description		DEAD-box helicase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Helicase Activity MRNA Binding Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Molecular Condensate Scaffold Activity
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Gamete Generation Germ Cell Development Spermatogenesis Cell Differentiation Flagellated Sperm Motility Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		PIWI-interacting RNA (piRNA) biogenesis RND3 GTPase cycle
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4
Entrez ID		54514
HPRD ID		05593
Ensembl ID		ENSG00000152670
Uniprot IDs		Q9NQI0
PDB IDs
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinucleolar Chromocenter Regulation Of Circadian Rhythm Positive Regulation Of Meiosis I Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Secondary PiRNA Processing PET Complex Positive Regulation Of Protein Metabolic Process Transposable Element Silencing By MRNA Destabilization PiRNA-mediated Gene Silencing By MRNA Destabilization Post-translational Protein Modification Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Regulation Of Meiosis I Germ-line Stem Cell Population Maintenance Dense Body PiRNA Binding Macromolecule Catabolic Process Rhythmic Process Pi-body Proteolysis Transposable Element Silencing By PiRNA-mediated DNA Methylation Chromatoid Body Negative Regulation Of Circadian Rhythm Positive Regulation Of Meiotic Nuclear Division PiRNA Processing Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Protein Polyubiquitination P Granule Regulation Of Protein Metabolic Process Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Meiotic Cell Cycle Protein Modification Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Polyubiquitination Microtubule Nucleation Regulation Of Meiotic Nuclear Division Microtubule Associated Complex RNA Endonuclease Activity Regulation Of Cytoplasmic Translation DNA Methylation-dependent Constitutive Heterochromatin Formation Cytoplasm
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