DDX4 and SPSB1

Number of citations of the paper that reports this interaction (PubMedID 20561531)
36

Data Source:
BioGRID (unspecified method)

		DDX4	SPSB1
Description		DEAD-box helicase 4	splA/ryanodine receptor domain and SOCS box containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Helicase Activity MRNA Binding Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Molecular Condensate Scaffold Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Gamete Generation Germ Cell Development Spermatogenesis Cell Differentiation Flagellated Sperm Motility Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		PIWI-interacting RNA (piRNA) biogenesis RND3 GTPase cycle	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)	A body shape index ( 34021172) Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 31562340 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 30578418 27841878) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4	14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A
Entrez ID		54514	80176
HPRD ID		05593	18106
Ensembl ID		ENSG00000152670	ENSG00000171621
Uniprot IDs		Q9NQI0	Q96BD6
PDB IDs			2JK9 3F2O
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinucleolar Chromocenter Regulation Of Circadian Rhythm Positive Regulation Of Meiosis I Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Secondary PiRNA Processing PET Complex Positive Regulation Of Protein Metabolic Process Transposable Element Silencing By MRNA Destabilization PiRNA-mediated Gene Silencing By MRNA Destabilization Post-translational Protein Modification Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Regulation Of Meiosis I Germ-line Stem Cell Population Maintenance Dense Body PiRNA Binding Macromolecule Catabolic Process Rhythmic Process Pi-body Proteolysis Transposable Element Silencing By PiRNA-mediated DNA Methylation Chromatoid Body Negative Regulation Of Circadian Rhythm Positive Regulation Of Meiotic Nuclear Division PiRNA Processing Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Protein Polyubiquitination P Granule Regulation Of Protein Metabolic Process Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Meiotic Cell Cycle Protein Modification Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Polyubiquitination Microtubule Nucleation Regulation Of Meiotic Nuclear Division Microtubule Associated Complex RNA Endonuclease Activity Regulation Of Cytoplasmic Translation DNA Methylation-dependent Constitutive Heterochromatin Formation Cytoplasm	Negative Regulation Of Metabolic Process Chromatin Remodeling Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Chromatin Organization Regulation Of DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Gene Expression Transferase Activity Regulation Of DNA Recombination Histone H3 Methyltransferase Activity Negative Regulation Of Catabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Enzyme Binding Negative Regulation Of Macromolecule Metabolic Process Methyltransferase Activity Negative Regulation Of B Cell Activation Determination Of Adult Lifespan Regulation Of Cell Communication Regulation Of Signaling Regulation Of Megakaryocyte Differentiation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Meiosis I Regulation Of Intracellular Signal Transduction Negative Regulation Of Double-strand Break Repair Methylation Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisomal Matrix Male Meiotic Nuclear Division Negative Regulation Of DNA Recombination Regulation Of Cellular Response To Stress Response To Starvation GATOR1 Complex Binding Hepatocyte Growth Factor Receptor Activity
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