DDX4 and SPSB4

Number of citations of the paper that reports this interaction (PubMedID 20561531)
36

Data Source:
BioGRID (unspecified method)

		DDX4	SPSB4
Description		DEAD-box helicase 4	splA/ryanodine receptor domain and SOCS box containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule Perinuclear Region Of Cytoplasm Pi-body PiP-body	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Helicase Activity MRNA Binding Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Molecular Condensate Scaffold Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Male Meiotic Nuclear Division Male Meiosis I Gamete Generation Germ Cell Development Spermatogenesis Cell Differentiation Flagellated Sperm Motility Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Polyubiquitination
Pathways		PIWI-interacting RNA (piRNA) biogenesis RND3 GTPase cycle	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010)	Ischemic stroke ( 24262325) Response to citalopram or escitalopram in depression ( 27622933) Schizophrenia x sex interaction ( 34099189) Stroke (ischemic) ( 23041239)
Interacting Genes		5 interacting genes: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4	2 interacting genes: DDX4 NOS2
Entrez ID		54514	92369
HPRD ID		05593	18108
Ensembl ID		ENSG00000152670	ENSG00000175093
Uniprot IDs		Q9NQI0	Q96A44
PDB IDs			2V24 6DN7 6DN8
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinucleolar Chromocenter Regulation Of Circadian Rhythm Positive Regulation Of Meiosis I Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Secondary PiRNA Processing PET Complex Positive Regulation Of Protein Metabolic Process Transposable Element Silencing By MRNA Destabilization PiRNA-mediated Gene Silencing By MRNA Destabilization Post-translational Protein Modification Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Regulation Of Meiosis I Germ-line Stem Cell Population Maintenance Dense Body PiRNA Binding Macromolecule Catabolic Process Rhythmic Process Pi-body Proteolysis Transposable Element Silencing By PiRNA-mediated DNA Methylation Chromatoid Body Negative Regulation Of Circadian Rhythm Positive Regulation Of Meiotic Nuclear Division PiRNA Processing Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Protein Polyubiquitination P Granule Regulation Of Protein Metabolic Process Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Meiotic Cell Cycle Protein Modification Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Polyubiquitination Microtubule Nucleation Regulation Of Meiotic Nuclear Division Microtubule Associated Complex RNA Endonuclease Activity Regulation Of Cytoplasmic Translation DNA Methylation-dependent Constitutive Heterochromatin Formation Cytoplasm	Nitric-oxide Synthase Activity Peptidyl-cysteine S-nitrosylation Tetrahydrobiopterin Binding Prostaglandin Secretion Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body Arginine Metabolic Process L-arginine Catabolic Process Perinuclear Region Of Cytoplasm Innate Immune Response In Mucosa Lipid Export From Cell Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Nitric Oxide Mediated Signal Transduction FMN Binding Arginine Binding Prostaglandin Transport Nitric Oxide Biosynthetic Process Pi-body Transposable Element Silencing By PiRNA-mediated DNA Methylation Regulatory NcRNA-mediated Heterochromatin Formation PiRNA Processing P Granule Transposable Element Silencing By Heterochromatin Formation Fc Receptor Mediated Stimulatory Signaling Pathway Male Meiosis I Cortical Cytoskeleton Mucosal Immune Response Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Organ Or Tissue Specific Immune Response Fc-gamma Receptor Signaling Pathway NADP Binding Negative Regulation Of Gene Expression Transposable Element Silencing Meiosis I DNA Methylation-dependent Constitutive Heterochromatin Formation Cell Redox Homeostasis Regulation Of Cellular Respiration Superoxide Metabolic Process Negative Regulation Of Blood Pressure Peroxisomal Matrix Male Meiotic Nuclear Division Molecular Condensate Scaffold Activity Fc Receptor Signaling Pathway Constitutive Heterochromatin Formation Glutamine Family Amino Acid Metabolic Process Flavin Adenine Dinucleotide Binding Positive Regulation Of Interleukin-8 Production Cellular Response To Xenobiotic Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity
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