PRMT7 and TRIO

Data Source: HiPPIP (Novel)

		PRMT7	TRIO
Name		protein arginine methyltransferase 7	trio Rho guanine nucleotide exchange factor
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol Extrinsic Component Of Membrane Cell Projection Presynaptic Active Zone Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Histone H4R3 Methyltransferase Activity Histone H4 Methyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Spliceosomal SnRNP Assembly Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Peptidyl-arginine Methylation Cell Differentiation Methylation Genomic Imprinting	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		RMTs methylate histone arginines	NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
GWAS		A body shape index ( 34021172 ) Birth weight ( 31043758 ) Body mass index ( 25673413 28892062 ) Lipoprotein (a) levels ( 33730874 ) Magnesium levels ( 20700443 ) Offspring birth weight ( 31043758 ) Refractive error ( 32231278 ) Schizophrenia ( 31579629 ) Serum metabolite levels ( 23093944 ) Weight ( 28552196 )	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145 ) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Asthma ( 31959851 ) Asthma (childhood onset) ( 31036433 ) Electroencephalogram traits ( 25387704 ) High density lipoprotein cholesterol levels ( 30498476 ) Intake of total sugars ( 31005972 ) Major depressive disorder ( 27777418 ) Paclitaxel-induced neuropathy ( 23776197 ) Physiological dysregulation (Mahalanobis distance) ( 32235003 ) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417 ) Waist circumference ( 28552196 )
Novel Interactors		1 novel interactors: TRIO	5 novel interactors: DAP DNAH5 MARCHF6 NIPBL PRMT7
Interacting Genes		14 interacting genes: CTCFL DIO3 EIF2S1 H2AC20 H3-5 H3C1 H4C1 MNDA NFKBID POT1 SNRPB UBC ZBTB24 ZNF438	13 interacting genes: BLMH CDC42 CDC5L DISC1 DSCR9 EXOC1 FLNA ITSN2 LIMS1 PTK2 PTPRF RAC1 RHOA
Entrez ID		54496	7204
HPRD ID		15174	03537
Ensembl ID		ENSG00000132600	ENSG00000038382
Uniprot IDs		A0A8I5KPP4 A0A8I5KXS9 A0A8I5KYD6 A0A8I5KZ05 A0A8I5KZ92 H3BNC0 Q9NVM4	O75962
PDB IDs		Not available	1NTY 2NZ8 6D8Z 7SJ4
GO Terms Enriched among Interactors		Structural Constituent Of Chromatin Nucleosome DNA Binding Chromosome Nucleus Protein Heterodimerization Activity Telomere Organization Translation Initiation Ternary Complex Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Retinal Cone Cell Apoptotic Process Thyroxine 5'-deiodinase Activity Thyroxine 5-deiodinase Activity Thyroid Hormone Catabolic Process Brown Fat Cell Proliferation Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Nucleoplasm SnRNP Binding U2 SnRNP Binding Chromatin Remodeling Epigenetic Regulation Of Gene Expression Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding	Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Junction Organization Focal Adhesion Cerebral Cortex Cell Migration Cell Motility Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Forebrain Cell Migration Membrane Invagination Positive Regulation Of Cell Migration Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Migration Positive Regulation Of Stress Fiber Assembly Cell Migration Positive Regulation Of Cell Motility Establishment Or Maintenance Of Cell Polarity Non-canonical Wnt Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Locomotion Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Projection Assembly Cell-cell Junction Organization Cell Cortex Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cytoskeleton Organization Thioesterase Binding G Protein Activity Cell Projection Organization Protein Kinase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Postsynapse Positive Regulation Of Neuron Migration Establishment Of Cell Polarity Positive Regulation Of Growth Regulation Of Neural Precursor Cell Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Establishment Of Epithelial Cell Apical/basal Polarity