PRMT7 and CTCFL

Number of citations of the paper that reports this interaction (PMID 17048991)
45

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		PRMT7	CTCFL
Gene Name		protein arginine methyltransferase 7	CCCTC-binding factor (zinc finger protein)-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane	Nucleus Cytoplasm
	Molecular Function	Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity [myelin Basic Protein]-arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific)	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Protein Binding Histone Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Spliceosomal SnRNP Assembly Chromatin Organization Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Cell Differentiation Histone Arginine Methylation DNA Methylation Involved In Gamete Generation Regulation Of Protein Binding Histone H4-R3 Methylation	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Cell Cycle Positive Regulation Of Gene Expression Histone Methylation DNA Methylation Involved In Gamete Generation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Histone H3-K4 Methylation
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Magnesium levels ( 20700443)	Obesity-related traits ( 23251661) Response to statin therapy ( 20339536) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		10 interactors: CTCFL DIO3 H3F3C HIST1H3A HIST1H4A HIST2H2AC MNDA POT1 SNRPB ZBTB24	7 interactors: BAG6 BRCA1 HIST1H1A HIST1H3A HIST2H2AC PRMT7 ZDHHC17
Entrez ID		54496	140690
HPRD ID		15174	09512
Ensembl ID		ENSG00000132600	ENSG00000124092
Uniprot IDs		Q9NVM4	A6XGM0 A6XGM9 A6XGN2 A6XGN4 Q8NI51
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Methylation DNA Modification DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Gene Expression, Epigenetic Cellular Aromatic Compound Metabolic Process Chromatin Silencing Cellular Nitrogen Compound Metabolic Process DNA Conformation Change Nitrogen Compound Metabolic Process Telomere Maintenance Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA Strand Elongation Chromosome Organization Methylation DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Silencing Thyroid Hormone Catabolic Process Heterocycle Metabolic Process Nucleosome Assembly Gene Expression Telomere Formation Via Telomerase Histone H4-K20 Demethylation Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Cellular Macromolecular Complex Assembly Negative Regulation Of Megakaryocyte Differentiation Protein-DNA Complex Assembly Positive Regulation Of Helicase Activity Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase DNA Packaging Chromatin Organization Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Hormone Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Growth Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cellular Component Assembly Regulation Of Telomerase Activity	Regulation Of Gene Expression By Genetic Imprinting Regulation Of Gene Expression, Epigenetic Genetic Imprinting Chromatin Organization Chromosome Organization DNA Methylation DNA Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Signal Transduction By P53 Class Mediator Nucleosome Assembly Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Positive Regulation Of Histone H3-K9 Acetylation Cellular Macromolecular Complex Assembly Gamete Generation Chromatin Assembly Organelle Organization Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Protein-DNA Complex Assembly Sexual Reproduction Cellular Component Assembly Multicellular Organismal Reproductive Process DNA Packaging Intrinsic Apoptotic Signaling Pathway Multicellular Organism Reproduction Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Chromosome Segregation Dosage Compensation By Inactivation Of X Chromosome Tail-anchored Membrane Protein Insertion Into ER Membrane Protein K6-linked Ubiquitination Protein Insertion Into ER Membrane Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Reproduction DNA Metabolic Process Histone H4-R3 Methylation DNA Replication-dependent Nucleosome Assembly DNA Conformation Change Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Peptidyl-arginine N-methylation Regulation Of Histone H4 Acetylation
Tagcloud ?			boundaries causal compact demethylation depleted finger functionally generating h3k27me3 inactive incorporation inducer insulator insulators iptg lac laci mark modification neighbouring ones preceded removes requirement separate spreading thereby variant
Tagcloud (Difference) ?			boundaries causal compact demethylation depleted finger functionally generating h3k27me3 inactive incorporation inducer insulator insulators iptg lac laci mark modification neighbouring ones preceded removes requirement separate spreading thereby variant
Tagcloud (Intersection) ?