TLR5

Name	toll like receptor 5
Structure
Interactors	5 interactors: MYD88 RNF216 SIGIRR TLR1 TLR4
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Male Gonad Development Positive Regulation Of Interleukin-8 Production Toll-like Receptor 5 Signaling Pathway Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus
Pathways	Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Diseases	Systemic lupus erythematosus
GWAS	Monocyte percentage of white cells ( 32888494 )
Entrez ID	7100
HPRD ID	04326
Ensembl ID	ENSG00000187554
Uniprot IDs	A0A2R8Y7Z4 O60602
PDB IDs	3J0A 8AR2
GO Terms Enriched among Interactors ?	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Chemokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Microglia Differentiation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-23 Production Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Inflammatory Response Detection Of Molecule Of Bacterial Origin Regulation Of Interleukin-6 Production NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Macrophage Cytokine Production Regulation Of Defense Response Cellular Response To Low-density Lipoprotein Particle Stimulus Detection Of Biotic Stimulus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cellular Response To Lipoprotein Particle Stimulus Regulation Of Macrophage Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Macrophage Differentiation Response To Molecule Of Bacterial Origin Cell Surface Toll-like Receptor Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production JNK Cascade Positive Regulation Of Interleukin-1 Beta Production Immune Response-regulating Signaling Pathway