TLR5 and MYD88

Number of citations of the paper that reports this interaction (PMID 15107846)
62

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TLR5	MYD88
Gene Name		toll-like receptor 5	myeloid differentiation primary response 88
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding	Death Receptor Binding Protein Binding Identical Protein Binding TIR Domain Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Male Gonad Development Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Mechanical Stimulus
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Innate Immune System	p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MYD88 RNF216 SIGIRR TLR1 TLR4	39 interactors: BTK CD93 CISH FADD FLII IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7
Entrez ID		7100	4615
HPRD ID		04326	03703
Ensembl ID		ENSG00000187554	ENSG00000172936
Uniprot IDs		O60602	J3KPU4 J3KQ87 J3KQJ6 Q99836
PDB IDs		1P95 3J0A	2JS7 2Z5V 3MOP 4DOM 4EO7
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Activation Of Innate Immune Response Detection Of Molecule Of Bacterial Origin Cellular Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Detection Of Biotic Stimulus Macrophage Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Fungus Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Regulation Of Immune System Process Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Immune Response-regulating Signaling Pathway Response To Bacterium Cellular Response To Mechanical Stimulus Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Other Organism Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Biotic Stimulus	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Defense Response Regulation Of Cytokine Production Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Interferon-beta Production Response To Other Organism I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Regulation Of Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Biotic Stimulus Toll-like Receptor 2 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Regulation Of Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-beta Production Regulation Of Intracellular Signal Transduction Response To External Stimulus Inflammatory Response Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Chemokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Interferon-alpha Production Regulation Of Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Chemokine Production
Tagcloud ?		adjuvanted alum anticocaine antihapten avenue benchmark boosting c4 cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics	binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Difference) ?		adjuvanted alum anticocaine antihapten avenue benchmark boosting c4 cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics	binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Intersection) ?