TLR5 and MYD88

Number of citations of the paper that reports this interaction (PubMedID 16482509)
45

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TLR5	MYD88
Description		toll like receptor 5	MYD88 innate immune signal transduction adaptor
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity	Signaling Receptor Binding Toll Binding Death Receptor Binding Cytokine Receptor Binding Interleukin-1 Receptor Binding Protein Binding Toll-like Receptor Binding Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity TIR Domain Binding ATP-dependent Histone Chaperone Activity
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Male Gonad Development Positive Regulation Of Interleukin-8 Production Toll-like Receptor 5 Signaling Pathway Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus	Response To Molecule Of Fungal Origin Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Organization Chromatin Remodeling Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway JNK Cascade Toll Signaling Pathway Response To Virus Induced Systemic Resistance Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Microglia Differentiation Response To Amine Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Neurogenesis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Interleukin-33-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Skin Development Innate Immune Response Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Neutrophil-mediated Killing Of Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Establishment Of Endothelial Intestinal Barrier Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Neutrophil Migration Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs
Diseases		Systemic lupus erythematosus
GWAS		Monocyte percentage of white cells ( 32888494)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4	44 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 NTAQ1 PELI2 PFKL POLR1C PRDX1 RAC1 RNF152 RNF4 SARM1 SIAH2 SMAD3 SPOP SPOPL STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7 ZNF35
Entrez ID		7100	4615
HPRD ID		04326	03703
Ensembl ID		ENSG00000187554	ENSG00000172936
Uniprot IDs		A0A2R8Y7Z4 O60602	A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 A0A494C0J8 Q99836
PDB IDs		3J0A 8AR2	2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N 7BEQ 7BER 7L6W 8S78 8W8M
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Chemokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Microglia Differentiation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-23 Production Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Inflammatory Response Detection Of Molecule Of Bacterial Origin Regulation Of Interleukin-6 Production NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Macrophage Cytokine Production Regulation Of Defense Response Cellular Response To Low-density Lipoprotein Particle Stimulus Detection Of Biotic Stimulus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cellular Response To Lipoprotein Particle Stimulus Regulation Of Macrophage Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Macrophage Differentiation Response To Molecule Of Bacterial Origin Cell Surface Toll-like Receptor Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production JNK Cascade Positive Regulation Of Interleukin-1 Beta Production Immune Response-regulating Signaling Pathway	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Defense Response To Other Organism Positive Regulation Of Immune Response Defense Response Positive Regulation Of Gene Expression Regulation Of Cytokine Production Response To Other Organism Defense Response To Symbiont Response To External Biotic Stimulus Positive Regulation Of Immune System Process Immune System Process Immune Response Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Regulation Of Interferon-beta Production Inflammatory Response Positive Regulation Of Interleukin-8 Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Interferon-beta Production Cell Surface Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-alpha Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-8 Production Interleukin-1-mediated Signaling Pathway
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