TOLLIP and CSTF1

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		TOLLIP	CSTF1
Gene Name		toll interacting protein	cleavage stimulation factor, 3 pre-RNA, subunit 1, 50kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Body Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Signal Transducer Activity Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding	RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Innate Immune Response Leukocyte Activation	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage RNA Processing RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPT1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WDYHV1 WRNIP1 XRN2 ZBTB16 ZHX1	5 interactors: BARD1 BRCA1 CSTF3 POLR2A TOLLIP
Entrez ID		54472	1477
HPRD ID		05887	02653
Ensembl ID		ENSG00000078902	ENSG00000101138
Uniprot IDs		B3KR28 B3KXC6 F2Z2Y8 Q6FIE9 Q9H0E2	Q05048
PDB IDs		1WGL
Enriched GO Terms of Interacting Partners?		Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Transcription, DNA-templated Negative Regulation Of Biosynthetic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Activation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Phosphorylation Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Metabolic Process Gene Expression Regulation Of Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter	Protein K6-linked Ubiquitination DNA Repair Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Transcription, RNA-templated Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Cellular Response To DNA Damage Stimulus Protein Polyubiquitination Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation DNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Protein Localization To Endosome Positive Regulation Of Metabolic Process Response To Stress RNA Splicing Cellular Response To Stress Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Protein Sumoylation MRNA Processing Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Negative Regulation Of Cell Cycle Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Acetylation MRNA Cleavage Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Regulation Of Protein Sumoylation Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Postreplication Repair
Tagcloud ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda
Tagcloud (Intersection) ?