FBXW5 and FAM168A

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		FBXW5	FAM168A
Description		F-box and WD repeat domain containing 5	family with sequence similarity 168 member A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Base-excision Repair
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30061609) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Waist-hip ratio ( 28552196)
Interacting Genes		36 interacting genes: ADAMTSL4 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	77 interacting genes: AKT1 ALKBH4 ATXN1 ATXN1L BOLL C10orf55 C1orf94 CALCOCO2 CAMK2A DAB1 DAZAP2 DCUN1D1 DTX2 EPN2 EPN3 FAM168B FBXW5 HGS HIP1 HR KLHL42 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP6-2 KRTAP7-1 KRTAP8-1 LASP1 MEIS2 NAF1 NFYC OTUB2 OTULIN PATZ1 PEF1 PITX1 PLEKHB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSORS1C1 R3HDM2 RBFOX1 RBPMS RBPMS2 RHOXF2 RNF216 RPS27A SECISBP2 SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TFAP2D TFG TIAL1 TNIP1 TNK1 TOLLIP UBA52 UBAC1 UBASH3B UBB UBC UBE2V1 UBQLN2 UBXN6 UBXN7 VPS37C YOD1 YTHDF1
Entrez ID		54461	23201
HPRD ID		10955	13792
Ensembl ID		ENSG00000159069	ENSG00000054965
Uniprot IDs		Q969U6	Q92567
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Interstitial Matrix Cytosol Structural Molecule Activity Supramolecular Fiber Organization Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription	Protein Tag Activity Intermediate Filament Post-translational Protein Modification Ubiquitin Protein Ligase Binding Protein Binding Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Cytoplasmic Stress Granule Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Autophagy Proteolysis Regulation Of Post-translational Protein Modification POZ Domain Binding Cytosol Positive Regulation Of Protein Monoubiquitination Identical Protein Binding Protein Modification Process Regulation Of Protein Monoubiquitination Glutamate Receptor Binding Clathrin-coated Vesicle Ubiquitin Conjugating Enzyme Binding RNA Stabilization Clathrin Binding Clathrin Vesicle Coat Regulation Of MRNA Metabolic Process Protein Metabolic Process Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Macroautophagy Negative Regulation Of RNA Catabolic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process MRNA Binding Protein K11-linked Deubiquitination RNA Binding Vesicle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Translational Initiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Sorting Pathway Ubiquitin Binding Proteasomal Protein Catabolic Process
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