FBXW5 and SASS6

Number of citations of the paper that reports this interaction (PubMedID 21725316)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		FBXW5	SASS6
Description		F-box and WD repeat domain containing 5	SAS-6 centriolar assembly protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Cytoplasm Centrosome Centriole Cytoskeleton Deuterosome Procentriole Replication Complex
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Centriole Replication Spermatogenesis Positive Regulation Of Centriole Replication Centrosome Duplication Regulation Of Mitotic Spindle Organization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Spindle Assembly
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Adiponectin levels ( 33562295)
Interacting Genes		36 interacting genes: ADAMTSL4 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	3 interacting genes: FBXW5 FCHSD2 FZR1
Entrez ID		54461	163786
HPRD ID		10955	10907
Ensembl ID		ENSG00000159069	ENSG00000156876
Uniprot IDs		Q969U6	B4DYM7 Q495U0 Q6UVJ0
PDB IDs			6YS4 6Z4A
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Interstitial Matrix Cytosol Structural Molecule Activity Supramolecular Fiber Organization Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription	Regulation Of Organelle Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Stereocilium Shaft DNA Synthesis Involved In Mitotic DNA Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Binding Thymidine Metabolic Process Ubiquitin-protein Transferase Activator Activity Thymidine Biosynthetic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Nuclear Division Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Actin Nucleation Pyrimidine Nucleoside Metabolic Process Ubiquitin Ligase Activator Activity Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Lens Fiber Cell Differentiation Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Anaphase-promoting Complex Protein Ubiquitination Phosphatidylinositol-3,4-bisphosphate Binding Regulation Of Arp2/3 Complex-mediated Actin Nucleation Anaphase-promoting Complex-dependent Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Senescence Cul4-RING E3 Ubiquitin Ligase Complex Neuromuscular Synaptic Transmission Clathrin-dependent Endocytosis Regulation Of Cell Cycle Process Regulation Of Meiotic Nuclear Division Regulation Of Actin Nucleation Mitotic G2 DNA Damage Checkpoint Signaling Phosphatidylinositol-3,4,5-trisphosphate Binding Post-translational Protein Modification Protein K11-linked Ubiquitination Pyrimidine-containing Compound Biosynthetic Process Stereocilium Nucleoside Metabolic Process Positive Regulation Of Actin Filament Polymerization Regulation Of Cellular Senescence Regulation Of Centrosome Duplication Mitotic G2/M Transition Checkpoint
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