FBXW5 and FBLN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBXW5	FBLN2
Description		F-box and WD repeat domain containing 5	fibulin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Extracellular Region Extracellular Matrix Extracellular Vesicle
	Molecular Function	Protein Binding Protein Kinase Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Cell-substrate Adhesion
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Appendicular lean mass ( 33097823) Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		36 interacting genes: ADAMTSL4 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	32 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HOXA1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 NUFIP2 OTX1 PRELP VCAN ZNF408 ZNF414
Entrez ID		54461	2199
HPRD ID		10955	00630
Ensembl ID		ENSG00000159069	ENSG00000163520
Uniprot IDs		Q969U6	P98095 Q86V58
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Interstitial Matrix Cytosol Structural Molecule Activity Supramolecular Fiber Organization Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription	Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Region Collagen-activated Signaling Pathway Cell Adhesion Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Extracellular Structure Organization Extracellular Matrix Organization Integrin Binding Lysosomal Lumen Perineuronal Net Glomerular Basement Membrane Development Skeletal System Development Golgi Lumen Angiogenesis System Development Hyaluronic Acid Binding Extracellular Matrix Binding Endodermal Cell Differentiation Retinal Blood Vessel Morphogenesis Extracellular Space Substrate Adhesion-dependent Cell Spreading Regulation Of Basement Membrane Organization Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Extracellular Matrix Constituent Conferring Elasticity Central Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin-like Growth Factor Stimulus Cell-substrate Adhesion Heparin Binding Branching Involved In Salivary Gland Morphogenesis Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Activity Protein Activation Cascade Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?