MC3R and AGRP

Number of citations of the paper that reports this interaction (PMID 9893984)
11

Data Source:
HPRD (in vitro)

		MC3R	AGRP
Gene Name		melanocortin 3 receptor	agouti related neuropeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space Golgi Lumen Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding	Receptor Binding Neuropeptide Hormone Activity
	Biological Process	Regulation Of Heart Rate G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of CAMP Biosynthetic Process Circadian Regulation Of Gene Expression Homoiothermy Sodium Ion Homeostasis	Neuropeptide Signaling Pathway Feeding Behavior Adult Feeding Behavior Photoperiodism Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AGRP ASIP POMC	4 interactors: GHRL MC3R MC4R MC5R
Entrez ID		4159	181
HPRD ID		01115	09079
Ensembl ID		ENSG00000124089	ENSG00000159723
Uniprot IDs		P41968	C6SUN5 O00253
PDB IDs			1HYK 1MR0 2IQV
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Cellular Pigmentation Neuropeptide Signaling Pathway Feeding Behavior Pigmentation Hormone-mediated Signaling Pathway Adult Behavior Regulation Of Molecular Function, Epigenetic Regulation Of Corticosterone Secretion Positive Regulation Of Feeding Behavior Generation Of Precursor Metabolites And Energy Single-organism Behavior Regulation Of Feeding Behavior Cellular Response To Hormone Stimulus Behavior Melanin Biosynthetic Process Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Pigment Granule Organization Secondary Metabolite Biosynthetic Process Photoperiodism Eating Behavior Cell-cell Signaling Genetic Imprinting Peptide Hormone Processing Melanosome Transport Pigment Granule Transport Response To Hormone Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Melanosome Localization G-protein Coupled Receptor Signaling Pathway Pigment Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Maternal Process Involved In Female Pregnancy Signal Transduction Regulation Of Lipid Transport Regulation Of Tumor Necrosis Factor Production Phenol-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Signaling Cell Communication Positive Regulation Of Behavior Cellular Response To Organic Substance Peptide Metabolic Process Regulation Of Carbohydrate Metabolic Process	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Peptide Hormone Secretion Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Feeding Behavior Positive Regulation Of Cellular Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cortisol Secretion Amide Transport Cell Surface Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Homoiothermy Regulation Of Behavior Positive Regulation Of Metabolic Process Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Regulation Of Hormone Levels Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Feeding Behavior Diet Induced Thermogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Growth Hormone Secretion Regulation Of Grooming Behavior Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Regulation Of Growth Hormone Secretion Gastric Acid Secretion Growth Hormone Secretion Response To Nutrient Levels Regulation Of Nitrogen Compound Metabolic Process Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Feeding Behavior
Tagcloud ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc4r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	agouti amphetamine atrophy cart cocaine contributor dawley focuses harvested histidine hypothalamic hypothalamus intraperitoneally ligases lps mafbx mh murf muscle neuropeptide neuropeptides npy pomc proopiomelanocortin sepsis septic sprague twelve wasting
Tagcloud (Difference) ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc4r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s	agouti amphetamine atrophy cart cocaine contributor dawley focuses harvested histidine hypothalamic hypothalamus intraperitoneally ligases lps mafbx mh murf muscle neuropeptide neuropeptides npy pomc proopiomelanocortin sepsis septic sprague twelve wasting
Tagcloud (Intersection) ?