MC3R

Gene Name		melanocortin 3 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Regulation Of Heart Rate G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of CAMP Biosynthetic Process Circadian Regulation Of Gene Expression Homoiothermy Sodium Ion Homeostasis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: AGRP ASIP POMC
Entrez ID		4159
HPRD ID		01115
Ensembl ID		ENSG00000124089
Uniprot IDs		P41968
PDB IDs
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Cellular Pigmentation Neuropeptide Signaling Pathway Feeding Behavior Pigmentation Hormone-mediated Signaling Pathway Adult Behavior Regulation Of Molecular Function, Epigenetic Regulation Of Corticosterone Secretion Positive Regulation Of Feeding Behavior Generation Of Precursor Metabolites And Energy Single-organism Behavior Regulation Of Feeding Behavior Cellular Response To Hormone Stimulus Behavior Melanin Biosynthetic Process Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Pigment Granule Organization Secondary Metabolite Biosynthetic Process Photoperiodism Eating Behavior Cell-cell Signaling Genetic Imprinting Peptide Hormone Processing Melanosome Transport Pigment Granule Transport Response To Hormone Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Melanosome Localization G-protein Coupled Receptor Signaling Pathway Pigment Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Maternal Process Involved In Female Pregnancy Signal Transduction Regulation Of Lipid Transport Regulation Of Tumor Necrosis Factor Production Phenol-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Signaling Cell Communication Positive Regulation Of Behavior Cellular Response To Organic Substance Peptide Metabolic Process Regulation Of Carbohydrate Metabolic Process
Tagcloud ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc4r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s