AVPR2 and AVP

Number of citations: 0 (PubMedID 11857925)
Data Source: HPRD (in vivo)

		AVPR2	AVP
Name		arginine vasopressin receptor 2	arginine vasopressin
Structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Binding Signaling Receptor Activity	Protein Kinase Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Retention Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Telencephalon Development Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Renal Water Absorption Positive Regulation Of Intracellular Signal Transduction	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Water Transport Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Salt Stress Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Multicellular Organismal Response To Stress Response To Testosterone Response To Nicotine Social Behavior Intracellular Signal Transduction Vasoconstriction Maternal Behavior Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Multicellular Organismal-level Water Homeostasis Response To Electrical Stimulus Negative Regulation Of Transmission Of Nerve Impulse Renal Water Absorption Blood Vessel Diameter Maintenance Response To Peptide Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Nerve Growth Factor
Pathways		Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	BMAL1:CLOCK,NPAS2 activates circadian expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Organic anion transport by SLCO transporters Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Drugs		Desmopressin Vasopressin Demeclocycline Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan Atosiban Lypressin Pecavaptan	None
Diseases		Congenital nephrogenic diabetes insipidus (NDI)	Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		10 interacting genes: ARRB2 AVP C1QTNF1 COMT FXYD6-FXYD2 GNAS GNB1 GNG2 GRK5 SLC41A1	9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17
Entrez ID		554	551
HPRD ID		02368	01891
Ensembl ID		ENSG00000126895	ENSG00000101200
Uniprot IDs		P30518	P01185 X5DQP6
PDB IDs		4JQI 6NI2 6U1N 7BB6 7BB7 7DF9 7DFA 7DFB 7DFC 7DW9 7KH0 7R0C 7R0J 8GOC 8I10 8JRU 8JRV 8WRZ 8WU1 9BT8 9CX3 9CX9	7BB6 7BB7 7DW9 7KH0 7R0C
GO Terms Enriched among Interactors		Response To Catecholamine Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Cellular Response To Prostaglandin E Stimulus Response To Alcohol G Protein-coupled Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Heterotrimeric G-protein Complex Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Renal System Process G Protein-coupled Receptor Signaling Pathway Response To Lipid Multicellular Organismal-level Water Homeostasis Regulation Of System Process Renal Absorption Response To Hormone Postsynaptic Signal Transduction Regulation Of Body Fluid Levels V1B Vasopressin Receptor Binding Norepinephrine Secretion Catechol O-methyltransferase Activity Plasma Membrane Multicellular Organismal Response To Stress Multicellular Organismal-level Chemical Homeostasis System Process Cellular Response To Hormone Stimulus Positive Regulation Of Transport Angiotensin Receptor Binding Nervous System Process V1A Vasopressin Receptor Binding Neurohypophyseal Hormone Activity Cellular Response To Phosphate Starvation Cellular Response To Oxygen-containing Compound Mu-type Opioid Receptor Binding Magnesium:sodium Antiporter Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Sensory Perception Of Chemical Stimulus Positive Regulation Of Aldosterone Secretion Sensory Perception Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Protein Localization To Extracellular Region Habituation Mastication Establishment Of Protein Localization To Extracellular Region Renal Sodium Excretion	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Vasopressin Receptor Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Regulation Of Vasoconstriction Positive Regulation Of Blood Pressure Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure Regulation Of Blood Circulation Vascular Process In Circulatory System Circulatory System Process Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity System Process Positive Regulation Of Systemic Arterial Blood Pressure Telencephalon Development Signal Transduction Regulation Of System Process G Protein-coupled Peptide Receptor Activity Response To Hormone Protein Kinase C Binding Positive Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Renal Water Retention Oxytocin Receptor Activity Endocytic Vesicle Regulation Of Biological Quality Transport Across Blood-brain Barrier Positive Regulation Of Multicellular Organismal Process V1A Vasopressin Receptor Binding Cerebral Cortex GABAergic Interneuron Fate Commitment Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Cellular Response To Water Deprivation Response To Water Deprivation Sperm Ejaculation Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Subpallium Development Positive Regulation Of Amacrine Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Protein-disulfide Reductase [NAD(P)H] Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Arachidonate Secretion Negative Regulation Of Urine Volume