AVPR2 and COMT

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		AVPR2	COMT
Name		arginine vasopressin receptor 2	catechol-O-methyltransferase
Structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Vesicle Synapse Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Binding Signaling Receptor Activity	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity Transferase Activity Metal Ion Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Retention Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Telencephalon Development Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Renal Water Absorption Positive Regulation Of Intracellular Signal Transduction	Behavioral Fear Response Response To Hypoxia Kidney Development Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Renin Secretion Into Blood Stream Glycogen Metabolic Process Catecholamine Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process Response To Stress Response To Oxidative Stress Learning Or Memory Learning Memory Regulation Of Blood Pressure Visual Learning Response To Temperature Stimulus Response To Xenobiotic Stimulus Response To Wounding Response To Toxic Substance Gene Expression Dopamine Secretion Cellular Response To Phosphate Starvation Cerebellar Cortex Morphogenesis Response To Food Methylation Developmental Process Glomerulus Development Cholesterol Efflux Multicellular Organismal Response To Stress Response To Cytokine Multicellular Organism Growth Exploration Behavior Renal Sodium Excretion Norepinephrine Metabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Fear Response Habituation Norepinephrine Secretion Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Response To Corticosterone Artery Development Cellular Response To Cocaine Mastication Renal Albumin Absorption Renal Filtration Response To Salt Response To Dopamine Response To Angiotensin
Pathways		Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS
Drugs		Desmopressin Vasopressin Demeclocycline Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan Atosiban Lypressin Pecavaptan	Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases		Congenital nephrogenic diabetes insipidus (NDI)	None
GWAS		No GWAS studies recorded	Serum metabolite levels ( 23093944 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )
Interacting Genes		10 interacting genes: ARRB2 AVP C1QTNF1 COMT FXYD6-FXYD2 GNAS GNB1 GNG2 GRK5 SLC41A1	68 interacting genes: ACE AQP7 AVPR2 BEST2 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HIBADH HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC71A2 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2
Entrez ID		554	1312
HPRD ID		02368	00284
Ensembl ID		ENSG00000126895	ENSG00000093010
Uniprot IDs		P30518	A0A140VJG8 P21964
PDB IDs		4JQI 6NI2 6U1N 7BB6 7BB7 7DF9 7DFA 7DFB 7DFC 7DW9 7KH0 7R0C 7R0J 8GOC 8I10 8JRU 8JRV 8WRZ 8WU1 9BT8 9CX3 9CX9	3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
GO Terms Enriched among Interactors		Response To Catecholamine Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Cellular Response To Prostaglandin E Stimulus Response To Alcohol G Protein-coupled Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Heterotrimeric G-protein Complex Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Renal System Process G Protein-coupled Receptor Signaling Pathway Response To Lipid Multicellular Organismal-level Water Homeostasis Regulation Of System Process Renal Absorption Response To Hormone Postsynaptic Signal Transduction Regulation Of Body Fluid Levels V1B Vasopressin Receptor Binding Norepinephrine Secretion Catechol O-methyltransferase Activity Plasma Membrane Multicellular Organismal Response To Stress Multicellular Organismal-level Chemical Homeostasis System Process Cellular Response To Hormone Stimulus Positive Regulation Of Transport Angiotensin Receptor Binding Nervous System Process V1A Vasopressin Receptor Binding Neurohypophyseal Hormone Activity Cellular Response To Phosphate Starvation Cellular Response To Oxygen-containing Compound Mu-type Opioid Receptor Binding Magnesium:sodium Antiporter Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Sensory Perception Of Chemical Stimulus Positive Regulation Of Aldosterone Secretion Sensory Perception Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Protein Localization To Extracellular Region Habituation Mastication Establishment Of Protein Localization To Extracellular Region Renal Sodium Excretion	Membrane Transmembrane Transport Plasma Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity G Protein-coupled Receptor Signaling Pathway Gap Junction Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nuclear Inner Membrane Regulation Of Blood Pressure Respiratory Burst After Phagocytosis Protein Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Blood Pressure Heme Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Regulation Of Gap Junction Assembly Respiratory Burst Involved In Defense Response